chrom pos ref alt rsids nearest_genes pval num_samples phenocode num_peaks gc_lambda_hundred phenostring arm cohort interaction participants category 8 1835801 T C rs12548513 ARHGEF10 9.1e-19 319.0 12.2.2_mixedlm_EUR 2 1.0254 Diastolic blood pressure at 6-months, adj. for baseline placebo European ancestry male European (Males) 6 40406855 A G rs4714346 LRFN2 1.3e-10 575.0 16.1.2_mixedlm_EUR 2 1.0027 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 10 50495309 CT C rs34473943 C10orf71 6.4e-10 959.0 15.2.2_gwama_inter_C_F_M_all 1 1.0054 Estimated glomerular filtration rate, % change placebo multi-ancestry sex all Multi-ancestry (All) 2 78755319 A G rs76822172 REG3G 1.1e-09 314.0 3.2.2_mixedlm_EUR 1 1.0283 Fasting glucose, % change placebo European ancestry male European (Males) 2 140888409 CT C rs564181702 LRP1B 1.6e-09 487.0 8.1.1_mixedlm_EUR 6 1.0254 Weight at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 6 168124563 G T rs613631 AFDN 1.9e-09 308.0 6.2.2_mixedlm_EUR 1 1.0313 Body mass index at 6-months, adj. for baseline placebo European ancestry male European (Males) 4 28845073 A G rs67221275 STIM2 2.4e-09 579.0 12.1.2_mixedlm_EUR 1 1.011 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 12 127058590 C T rs74823582 TMEM132B 2.7e-09 315.0 15.2.2_mixedlm_EUR 1 1.011 Estimated glomerular filtration rate, % change placebo European ancestry male European (Males) 7 12559831 T G rs10234141 AC013470.2 3.2e-09 864.0 21.1.3_gmmat_all 3 1.0 Hypoglycemic events saxagliptin multi-ancestry female Multi-ancestry (Females) 6 51297371 CT CTT PKHD1 3.4e-09 889.0 1.2_gwama_inter_I_male_vs_C_males_EUR 2 1.011 HbA1c, % change both European ancestry treatment male European (Males) 3 153505405 T G rs12636024 ARHGEF26 3.6e-09 985.0 5.1.1_mixedlm_EUR 1 1.0 Body mass index, % change saxagliptin European ancestry all European (All) 3 152761474 T G rs17454914 RAP2B 4e-09 947.0 14.1.2_gmmat_all 1 1.0054 Heart rate at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 4 8101795 G C rs4631023 ABLIM2 4e-09 269.0 8.2.2_gmmat_all 5 1.0375 Weight at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 3 62726213 C G rs3846216 CADPS 5.6e-09 1421.0 5.1.2_gwama_inter_I_male_vs_C_males_all 1 0.97444 Body mass index, % change both multi-ancestry treatment male Multi-ancestry (Males) 4 24505082 T C rs12644451 DHX15 7.3e-09 1501.0 1.1_gwama_inter_I_all_vs_C_all_EUR 1 1.0138 HbA1c, % change both European ancestry treatment all European (All) 6 165126617 G A rs9356253 C6orf118 8.1e-09 889.0 2.2_gwama_inter_I_male_vs_C_males_EUR 1 1.0 HbA1c at 6-months, adj. for baseline both European ancestry treatment male European (Males) 21 20181693 T G rs2156204 TMPRSS15 8.4e-09 1794.0 13.1.1_gmmat_all 1 1.0082 Heart rate, % change saxagliptin multi-ancestry all Multi-ancestry (All) 3 99344266 C T rs62281788 COL8A1 8.5e-09 397.0 8.1.2_gmmat_all 7 1.0437 Weight at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 3 53910117 G GA ACTR8 1e-08 1460.0 4.1.2_gwama_inter_I_male_vs_C_males_all 1 1.0 Fasting glucose at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 1 153258751 GAAGA G rs151285452 PGLYRP3 1.1e-08 935.0 16.1.2_gmmat_all 1 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 5 7519762 G A rs6867567 ADCY2 1.1e-08 653.0 18.1.3_gmmat_all 2 0.97444 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 18 29789095 T G rs76393137 GAREM1,MEP1B 1.2e-08 207.0 12.2.3_mixedlm_EUR 1 1.0313 Diastolic blood pressure at 6-months, adj. for baseline placebo European ancestry female European (Females) 9 96359281 C T rs113617970 PHF2 1.2e-08 1003.0 12.4_gwama_inter_I_F_M_EUR 2 1.0166 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin European ancestry sex all European (All) 1 49065763 T G rs79907326 AGBL4 1.2e-08 325.0 8.2.1_mixedlm_EUR 1 1.0027 Weight at 6-months, adj. for baseline placebo European ancestry all European (All) X 71138226 TA T rs11333019 NHSL2 1.3e-08 995.0 16.1.1_mixedlm_EUR 1 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 16 49879988 G A rs35332951 ZNF423 1.4e-08 875.0 6.2_gwama_inter_I_male_vs_C_males_EUR 1 1.0224 Body mass index at 6-months, adj. for baseline both European ancestry treatment male European (Males) 9 101208288 C A rs17770298 GABBR2 1.5e-08 947.0 9.1.2_gmmat_all 1 0.97444 Systolic blood pressure, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 2 78675036 G T rs116632958 REG3G 1.8e-08 516.0 3.2.1_mixedlm_EUR 1 1.0375 Fasting glucose, % change placebo European ancestry all European (All) 4 28848381 C CT STIM2 1.9e-08 579.0 11.1.2_mixedlm_EUR 1 1.011 Diastolic blood pressure, % change saxagliptin European ancestry male European (Males) 17 522197 T C rs62056500 VPS53 1.9e-08 980.0 21.2.1_gmmat_all 2 0.97444 Hypoglycemic events placebo multi-ancestry all Multi-ancestry (All) 21 26034093 C A rs2829239 MRPL39 2e-08 960.0 9.2.1_gmmat_all 1 1.0027 Systolic blood pressure, % change placebo multi-ancestry all Multi-ancestry (All) 1 72599680 A G rs77844954 NEGR1 2.2e-08 935.0 2.1.2_gmmat_all 1 1.0054 HbA1c at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 4 35096282 A T rs374103321 ARAP2 2.4e-08 1003.0 11.1.1_mixedlm_EUR 1 0.9298 Diastolic blood pressure, % change saxagliptin European ancestry all European (All) 2 159305479 G A rs1978403 CCDC148 2.6e-08 522.0 2.2.2_gmmat_all 1 1.0 HbA1c at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 21 23205368 T TC rs57209003 NCAM2 2.8e-08 516.0 2.2.1_mixedlm_EUR 2 1.0166 HbA1c at 6-months, adj. for baseline placebo European ancestry all European (All) 9 752104 G T rs12002168 KANK1 2.8e-08 481.0 7.2.1_gmmat_all 2 1.0 Weight, % change placebo multi-ancestry all Multi-ancestry (All) 15 40635859 C T rs71472431 CCDC9B 3e-08 315.0 16.2.2_mixedlm_EUR 2 1.0254 Estimated glomerular filtration rate at 6-months, adj. for baseline placebo European ancestry male European (Males) 17 522197 T C rs62056500 VPS53 3.2e-08 532.0 21.2.1_coxph_EUR 1 1.011 Hypoglycemic events placebo European ancestry all European (All) 20 31991141 CA C CDK5RAP1 3.3e-08 1003.0 12.1.1_mixedlm_EUR 2 1.0 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 14 31530164 C T rs35832522 AP4S1 3.3e-08 812.0 8.1_gwama_inter_I_all_vs_C_all_EUR 2 1.0138 Weight at 6-months, adj. for baseline both European ancestry treatment all European (All) 8 8220441 T C rs71513189 PRAG1 3.4e-08 412.0 1.1.3_mixedlm_EUR 1 1.0082 HbA1c, % change saxagliptin European ancestry female European (Females) 19 363083 G A rs73506546 THEG 3.5e-08 631.0 12.3_gwama_inter_I_females_vs_C_females_EUR 1 1.0254 Diastolic blood pressure at 6-months, adj. for baseline both European ancestry treatment female European (Females) 2 201351188 G T rs17630975 KCTD18 3.6e-08 414.0 3.1.3_mixedlm_EUR 1 1.0254 Fasting glucose, % change saxagliptin European ancestry female European (Females) 6 159126324 G A rs112845669 SYTL3 3.7e-08 526.0 10.2.1_mixedlm_EUR 1 1.0283 Systolic blood pressure at 6-months, adj. for baseline placebo European ancestry all European (All) 20 5353790 CT C PROKR2 3.9e-08 2762.0 10.1.1_gwama_inter_I_all_vs_C_all_all 1 1.0027 Systolic blood pressure at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 3 34885715 C CCA ARPP21 4.2e-08 524.0 14.2.2_gmmat_all 1 1.0082 Heart rate at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 10 97207044 G SORBS1 4.3e-08 314.0 4.2.2_mixedlm_EUR 1 1.0166 Fasting glucose at 6-months, adj. for baseline placebo European ancestry male European (Males) 5 25895231 CAAAA C rs35489945 CDH9 4.3e-08 294.0 8.1.3_gmmat_all 2 1.0082 Weight at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 9 23368985 C A rs10965808 ELAVL2 4.5e-08 985.0 2.4_gwama_inter_I_F_M_EUR 1 1.0054 HbA1c at 6-months, adj. for baseline saxagliptin European ancestry sex all European (All) 3 66354122 T C rs10865666 SLC25A26 4.5e-08 199.0 5.2.3_mixedlm_EUR 1 1.0254 Body mass index, % change placebo European ancestry female European (Females) 6 86851114 T A rs34580458 SYNCRIP 4.7e-08 536.0 21.2.2_gmmat_all 1 0.97444 Hypoglycemic events placebo multi-ancestry male Multi-ancestry (Males) 3 34885715 C CCA ARPP21 5.2e-08 521.0 13.2.2_gmmat_all 0 1.0 Heart rate, % change placebo multi-ancestry male Multi-ancestry (Males) 14 97558285 AAAC A VRK1 5.2e-08 831.0 5.1.3_gmmat_all 0 1.0 Body mass index, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 3 153505405 T G rs12636024 ARHGEF26 5.2e-08 985.0 6.1.1_mixedlm_EUR 0 1.0 Body mass index at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 12 67183423 CTATT C rs10535108 GRIP1 5.6e-08 200.0 1.2.3_mixedlm_EUR 0 1.0166 HbA1c, % change placebo European ancestry female European (Females) 12 69467073 G C rs7958303 CPM 5.9e-08 959.0 11.2.2_gwama_inter_C_F_M_all 0 1.0 Diastolic blood pressure, % change placebo multi-ancestry sex all Multi-ancestry (All) 3 1256946 C T rs72999894 CNTN6 5.9e-08 1003.0 13.1.1_mixedlm_EUR 0 1.0138 Heart rate, % change saxagliptin European ancestry all European (All) 7 96967998 A T rs141250684 SDHAF3 6.1e-08 319.0 13.2.2_mixedlm_EUR 0 1.0138 Heart rate, % change placebo European ancestry male European (Males) 10 86635236 C T rs138558907 CCSER2 6.1e-08 1016.0 21.1.1_coxph_EUR 0 1.0 Hypoglycemic events saxagliptin European ancestry all European (All) 10 127841158 A T rs1674908 ADAM12 6.2e-08 954.0 1.2.2_gwama_inter_C_F_M_all 0 1.0 HbA1c, % change placebo multi-ancestry sex all Multi-ancestry (All) 12 43632595 T G rs10880445 ADAMTS20 6.2e-08 2735.0 2.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0138 HbA1c at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 12 82126292 T TA PPFIA2 6.2e-08 2737.0 4.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0082 Fasting glucose at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 15 93786630 GAGAT G rs141016712 RGMA 6.3e-08 424.0 13.1.3_mixedlm_EUR 0 1.0082 Heart rate, % change saxagliptin European ancestry female European (Females) 5 150920566 G A rs2288778 FAT2 6.4e-08 1780.0 4.1.1_gmmat_all 0 1.0 Fasting glucose at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 3 60169681 C T rs213423 FHIT 6.4e-08 424.0 9.1.3_mixedlm_EUR 0 1.0054 Systolic blood pressure, % change saxagliptin European ancestry female European (Females) 4 97586569 T C rs4576092 STPG2 6.6e-08 325.0 7.2.1_mixedlm_EUR 0 1.0195 Weight, % change placebo European ancestry all European (All) 10 133460618 C T rs72853629 PPP2R2D 6.6e-08 691.0 8.1.1_gmmat_all 0 1.0082 Weight at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 8 16635861 A G rs58485217 MSR1 6.8e-08 1781.0 2.1.2_gwama_inter_I_F_M_all 0 1.0 HbA1c at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 3 60169681 C T rs213423 FHIT 6.9e-08 424.0 10.1.3_mixedlm_EUR 0 1.0027 Systolic blood pressure at 6-months, adj. for baseline saxagliptin European ancestry female European (Females) 4 599688 G A rs56283233 PDE6B 7e-08 883.0 3.2_gwama_inter_I_male_vs_C_males_EUR 0 1.0 Fasting glucose, % change both European ancestry treatment male European (Males) 11 134763958 G A rs4290245 B3GAT1 7.1e-08 316.0 2.2.2_mixedlm_EUR 0 1.0138 HbA1c at 6-months, adj. for baseline placebo European ancestry male European (Males) 7 141135114 G A rs10224927 TMEM178B 7.2e-08 846.0 2.1.3_gmmat_all 0 1.0 HbA1c at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 7 220326 G A rs55712175 FAM20C 7.3e-08 526.0 12.5_gwama_inter_C_F_M_EUR 0 1.0054 Diastolic blood pressure at 6-months, adj. for baseline placebo European ancestry sex all European (All) 4 128118705 G A rs77030524 INTU 7.4e-08 937.0 4.1.2_gmmat_all 0 1.0027 Fasting glucose at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 2 80227984 C G rs636935 CTNNA2 7.5e-08 327.0 18.1.3_mixedlm_EUR 0 1.0082 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin European ancestry female European (Females) 4 63103865 T G rs112855545 ADGRL3 7.9e-08 921.0 6.2.1_gmmat_all 0 1.0027 Body mass index at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 10 39072124 T C rs138664479 LINC00999 8e-08 666.0 8.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0254 Weight at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 2 47046581 CAA C SOCS5 8.1e-08 325.0 17.1.3_mixedlm_EUR 0 1.0195 Urine albumin-to-creatinine ratio, % change saxagliptin European ancestry female European (Females) 18 46327155 G A rs76667091 CTIF 8.2e-08 1492.0 6.1_gwama_inter_I_all_vs_C_all_EUR 0 1.0054 Body mass index at 6-months, adj. for baseline both European ancestry treatment all European (All) 7 80805175 T A rs1509911 SEMA3C 8.4e-08 2751.0 13.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0 Heart rate, % change both multi-ancestry treatment all Multi-ancestry (All) 2 129205437 G A rs139440962 HS6ST1 8.4e-08 526.0 9.2.1_mixedlm_EUR 0 1.4685 Systolic blood pressure, % change placebo European ancestry all European (All) X 95047839 CT C DIAPH2 8.5e-08 450.0 18.1.2_mixedlm_EUR 0 0.97444 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 7 77742537 A C rs62461188 MAGI2 8.8e-08 851.0 10.1.3_gmmat_all 0 1.0 Systolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 15 90412799 TAA T AP3S2,ARPIN-AP3S2 8.8e-08 631.0 9.3_gwama_inter_I_females_vs_C_females_EUR 0 1.0166 Systolic blood pressure, % change both European ancestry treatment female European (Females) 1 217089102 C A rs34783704 ESRRG 8.9e-08 1475.0 10.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0027 Systolic blood pressure at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 3 1257521 A AT rs149459522 CNTN6 9.7e-08 579.0 13.1.2_mixedlm_EUR 0 1.0166 Heart rate, % change saxagliptin European ancestry male European (Males) 1 16337252 C T rs1739836 SRARP 1e-07 957.0 13.2.1_gmmat_all 0 1.0 Heart rate, % change placebo multi-ancestry all Multi-ancestry (All) 3 23819172 T C rs2168426 UBE2E1 1e-07 985.0 2.1.1_mixedlm_EUR 0 1.0 HbA1c at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 5 153584363 A G rs4958711 GALNT10,MFAP3 1e-07 924.0 6.1.2_gmmat_all 0 1.0054 Body mass index at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 13 26548451 A G rs4770890 ATP8A2 1e-07 418.0 6.1.3_mixedlm_EUR 0 1.011 Body mass index at 6-months, adj. for baseline saxagliptin European ancestry female European (Females) 18 12235540 C T rs74917877 CIDEA 1.1e-07 890.0 16.2_gwama_inter_I_male_vs_C_males_EUR 0 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline both European ancestry treatment male European (Males) 9 28495767 A C rs10968617 LINGO2 1.1e-07 953.0 3.2.1_gmmat_all 0 1.0027 Fasting glucose, % change placebo multi-ancestry all Multi-ancestry (All) 7 129397484 CA C NRF1 1.1e-07 1756.0 6.1.1_gmmat_all 0 1.0 Body mass index at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 7 74426130 G A rs144458482 CASTOR2 1.1e-07 507.0 6.2.1_mixedlm_EUR 0 1.0 Body mass index at 6-months, adj. for baseline placebo European ancestry all European (All) 2 157022586 T C rs17187573 NR4A2 1.2e-07 1501.0 2.1_gwama_inter_I_all_vs_C_all_EUR 0 1.011 HbA1c at 6-months, adj. for baseline both European ancestry treatment all European (All) 16 24455965 TA T rs371523491 CACNG3 1.2e-07 616.0 3.3_gwama_inter_I_females_vs_C_females_EUR 0 1.0027 Fasting glucose, % change both European ancestry treatment female European (Females) 2 201351188 G T rs17630975 KCTD18 1.2e-07 414.0 4.1.3_mixedlm_EUR 0 1.0166 Fasting glucose at 6-months, adj. for baseline saxagliptin European ancestry female European (Females) 4 94766621 T C rs7693338 ATOH1 1.2e-07 434.0 4.2.3_gmmat_all 0 1.0082 Fasting glucose at 6-months, adj. for baseline placebo multi-ancestry female Multi-ancestry (Females) 2 85183070 G C rs148185493 KCMF1 1.2e-07 504.0 6.2.2_gmmat_all 0 1.011 Body mass index at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 7 134901282 TAC T rs71174507 WDR91 1.2e-07 691.0 8.1.2_gwama_inter_I_F_M_all 0 1.0082 Weight at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 12 130781878 T C rs10466889 PIWIL1 1.3e-07 319.0 10.2.2_mixedlm_EUR 0 1.0406 Systolic blood pressure at 6-months, adj. for baseline placebo European ancestry male European (Males) 1 17240551 TCCCCGCCCCGTGGCGGGGACG T rs150160215 CROCC 1.3e-07 898.0 10.2_gwama_inter_I_male_vs_C_males_EUR 0 1.0283 Systolic blood pressure at 6-months, adj. for baseline both European ancestry treatment male European (Males) 3 152833810 G A rs56107526 RAP2B 1.3e-07 1796.0 14.1.1_gmmat_all 0 1.0082 Heart rate at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) X 84615532 GTA G POF1B 1.3e-07 420.0 16.1.3_mixedlm_EUR 0 1.0027 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin European ancestry female European (Females) 8 137802025 C T rs71530187 KHDRBS3 1.3e-07 569.0 3.1.2_mixedlm_EUR 0 1.0054 Fasting glucose, % change saxagliptin European ancestry male European (Males) 15 90412799 TAA T AP3S2,ARPIN-AP3S2 1.4e-07 631.0 10.3_gwama_inter_I_females_vs_C_females_EUR 0 1.0195 Systolic blood pressure at 6-months, adj. for baseline both European ancestry treatment female European (Females) 5 135028007 C CA SLC25A48 1.4e-07 434.0 11.2.3_gmmat_all 0 1.0 Diastolic blood pressure, % change placebo multi-ancestry female Multi-ancestry (Females) 1 153265396 G C rs67401364 PGLYRP3 1.4e-07 933.0 15.1.2_gmmat_all 0 1.0 Estimated glomerular filtration rate, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 12 84541558 C CT SLC6A15 1.4e-07 1282.0 15.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Estimated glomerular filtration rate, % change both multi-ancestry treatment female Multi-ancestry (Females) 2 12786284 A G rs35855677 TRIB2 1.4e-07 770.0 18.2.1_gmmat_all 0 1.0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 2 105063075 T G rs73946460 POU3F3 1.4e-07 1458.0 3.1.2_gwama_inter_I_male_vs_C_males_all 0 0.97444 Fasting glucose, % change both multi-ancestry treatment male Multi-ancestry (Males) 12 99215691 C CT ANKS1B 1.5e-07 959.0 11.2.1_gmmat_all 0 1.0082 Diastolic blood pressure, % change placebo multi-ancestry all Multi-ancestry (All) 4 28833637 C G rs2029668 STIM2 1.5e-07 1003.0 11.4_gwama_inter_I_F_M_EUR 0 1.011 Diastolic blood pressure, % change saxagliptin European ancestry sex all European (All) 3 120250293 T G rs1982187 NDUFB4 1.5e-07 1182.0 18.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 3 145284477 G GTATCTATC PLOD2 1.5e-07 417.0 6.2.3_gmmat_all 0 1.0054 Body mass index at 6-months, adj. for baseline placebo multi-ancestry female Multi-ancestry (Females) 4 159381989 C A rs936091 RXFP1 1.5e-07 1798.0 9.1.2_gwama_inter_I_F_M_all 0 1.0 Systolic blood pressure, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) 1 160613894 C T rs41463446 SLAMF1 1.6e-07 777.0 18.1.1_mixedlm_EUR 0 1.011 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 4 95601777 G A rs77007938 PDLIM5 1.6e-07 1826.0 21.1.1_gmmat_all 0 1.0 Hypoglycemic events saxagliptin multi-ancestry all Multi-ancestry (All) 21 41332464 C T rs74518163 PCP4 1.6e-07 268.0 7.2.2_gmmat_all 0 1.0 Weight, % change placebo multi-ancestry male Multi-ancestry (Males) 1 85172587 C A rs79075460 SSX2IP 1.6e-07 207.0 9.2.3_mixedlm_EUR 0 1.0344 Systolic blood pressure, % change placebo European ancestry female European (Females) 6 129422405 C A rs7751685 LAMA2 1.7e-07 1003.0 10.4_gwama_inter_I_F_M_EUR 0 1.0 Systolic blood pressure at 6-months, adj. for baseline saxagliptin European ancestry sex all European (All) 3 124551967 C T rs4141663 ITGB5 1.7e-07 1548.0 21.1_gwama_inter_I_all_vs_C_all_EUR 0 0.97444 Hypoglycemic events both European ancestry treatment all European (All) X 70621851 A G rs28382184 TAF1 1.7e-07 1776.0 3.1.2_gwama_inter_I_F_M_all 0 1.0 Fasting glucose, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) X 130892672 G C rs143393674 IGSF1 1.8e-07 316.0 1.2.2_mixedlm_EUR 0 1.0313 HbA1c, % change placebo European ancestry male European (Males) 19 17505859 C T rs8102244 CCDC194 1.8e-07 1454.0 15.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0 Estimated glomerular filtration rate, % change both multi-ancestry treatment male Multi-ancestry (Males) 3 2483305 G A rs2648694 CNTN4 1.8e-07 2183.0 17.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0027 Urine albumin-to-creatinine ratio, % change both multi-ancestry treatment all Multi-ancestry (All) 5 85010377 T A rs7729979 COX7C 1.8e-07 1457.0 2.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0027 HbA1c at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 7 147755391 A G rs6971366 CNTNAP2 1.8e-07 1780.0 4.1.2_gwama_inter_I_F_M_all 0 1.0 Fasting glucose at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 16 49683528 A C rs2216059 ZNF423 1.8e-07 1003.0 9.1.1_mixedlm_EUR 0 0.97444 Systolic blood pressure, % change saxagliptin European ancestry all European (All) 4 110683345 T TAAAA AC126283.1,CFI 1.9e-07 1455.0 1.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0082 HbA1c, % change both multi-ancestry treatment male Multi-ancestry (Males) 5 43231984 TC T rs78014759 NIM1K 1.9e-07 579.0 9.1.2_mixedlm_EUR 0 1.0138 Systolic blood pressure, % change saxagliptin European ancestry male European (Males) 15 45719187 G C rs17536527 C15orf48 2e-07 1782.0 16.1.1_gmmat_all 0 0.97444 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 1 86004817 T G rs1882936 DDAH1 2.1e-07 526.0 10.5_gwama_inter_C_F_M_EUR 0 1.0054 Systolic blood pressure at 6-months, adj. for baseline placebo European ancestry sex all European (All) 10 1447105 G T rs11250496 ADARB2 2.2e-07 436.0 12.2.3_gmmat_all 0 1.0 Diastolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry female Multi-ancestry (Females) 12 82126292 T TA PPFIA2 2.2e-07 957.0 4.2.1_gmmat_all 0 1.011 Fasting glucose at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 10 2050303 G A rs35168688 ADARB2 2.3e-07 612.0 1.3_gwama_inter_I_females_vs_C_females_EUR 0 1.0283 HbA1c, % change both European ancestry treatment female European (Females) 7 141122380 G C rs7800347 TMEM178B 2.3e-07 1003.0 13.4_gwama_inter_I_F_M_EUR 0 1.0 Heart rate, % change saxagliptin European ancestry sex all European (All) 15 70925726 C T rs12904891 UACA 2.3e-07 319.0 14.2.2_mixedlm_EUR 0 1.0344 Heart rate at 6-months, adj. for baseline placebo European ancestry male European (Males) 7 103366870 C G rs565901 RELN 2.3e-07 1278.0 2.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0166 HbA1c at 6-months, adj. for baseline both multi-ancestry treatment female Multi-ancestry (Females) 6 24474402 T C rs57950928 GPLD1 2.5e-07 948.0 12.1.2_gmmat_all 0 1.0 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 3 194774716 T C rs2222146 XXYLT1 2.5e-07 962.0 12.2.2_gwama_inter_C_F_M_all 0 1.0 Diastolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry sex all Multi-ancestry (All) 1 110962800 T G rs3893159 LAMTOR5 2.6e-07 579.0 10.1.2_mixedlm_EUR 0 1.0082 Systolic blood pressure at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 7 148327483 T C rs713591 C7orf33 2.6e-07 2757.0 11.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0054 Diastolic blood pressure, % change both multi-ancestry treatment all Multi-ancestry (All) X 84615532 GTA G POF1B 2.6e-07 995.0 16.4_gwama_inter_I_F_M_EUR 0 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin European ancestry sex all European (All) 7 158314218 C T rs10259438 PTPRN2 2.6e-07 486.0 7.1.1_mixedlm_EUR 0 1.0224 Weight, % change saxagliptin European ancestry all European (All) 1 22912914 C T rs183497128 EPHA8 2.6e-07 1798.0 9.1.1_gmmat_all 0 0.97444 Systolic blood pressure, % change saxagliptin multi-ancestry all Multi-ancestry (All) 3 192764993 G C rs7653679 MB21D2 2.6e-07 319.0 9.2.2_mixedlm_EUR 0 1.0283 Systolic blood pressure, % change placebo European ancestry male European (Males) 1 239155348 T A rs76747138 CHRM3 2.7e-07 202.0 4.2.3_mixedlm_EUR 0 1.0082 Fasting glucose at 6-months, adj. for baseline placebo European ancestry female European (Females) 4 95103782 G T rs144228418 SMARCAD1 2.8e-07 1779.0 1.1.1_gmmat_all 0 1.0 HbA1c, % change saxagliptin multi-ancestry all Multi-ancestry (All) 1 110907121 CTT C SLC16A4 2.8e-07 1799.0 10.1.2_gwama_inter_I_F_M_all 0 1.0 Systolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) X 172929 T C rs28698141 ENSG00000182378.15_10 2.8e-07 436.0 13.2.3_gmmat_all 0 1.0 Heart rate, % change placebo multi-ancestry female Multi-ancestry (Females) 1 177494053 GA G rs10716131 BRINP2 2.8e-07 1003.0 14.1.1_mixedlm_EUR 0 1.0254 Heart rate at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 18 7434765 C T rs12373198 PTPRM 2.8e-07 415.0 5.2.3_gmmat_all 0 1.0 Body mass index, % change placebo multi-ancestry female Multi-ancestry (Females) 10 80020890 T C rs57004307 RPS24 2.8e-07 483.0 8.2.1_gmmat_all 0 1.0283 Weight at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 3 109453564 C CA DPPA4 2.8e-07 526.0 9.5_gwama_inter_C_F_M_EUR 0 1.0 Systolic blood pressure, % change placebo European ancestry sex all European (All) 10 68355089 TTTA T CTNNA3 2.9e-07 1798.0 11.1.2_gwama_inter_I_F_M_all 0 1.0027 Diastolic blood pressure, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) 19 56795496 G A rs8104696 EDDM13,ZSCAN5A 2.9e-07 1277.0 4.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0138 Fasting glucose at 6-months, adj. for baseline both multi-ancestry treatment female Multi-ancestry (Females) 22 31051450 G A rs201087159 DUSP18,SLC35E4 2.9e-07 875.0 5.2_gwama_inter_I_male_vs_C_males_EUR 0 1.011 Body mass index, % change both European ancestry treatment male European (Males) 3 43981374 C A rs11130018 ABHD5 3e-07 424.0 12.1.3_mixedlm_EUR 0 1.011 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin European ancestry female European (Females) 12 10561279 C G rs2617171 KLRC4,KLRC4-KLRK1 3e-07 776.0 18.4_gwama_inter_I_F_M_EUR 0 0.97444 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin European ancestry sex all European (All) 12 95209562 T C rs4761507 NDUFA12 3e-07 200.0 2.2.3_mixedlm_EUR 0 1.0224 HbA1c at 6-months, adj. for baseline placebo European ancestry female European (Females) 12 20218444 T A rs5796847 PDE3A 3e-07 1750.0 5.1.1_gmmat_all 0 1.0 Body mass index, % change saxagliptin multi-ancestry all Multi-ancestry (All) 4 54170130 G A rs13102168 SCFD2 3e-07 617.0 5.3_gwama_inter_I_females_vs_C_females_EUR 0 1.011 Body mass index, % change both European ancestry treatment female European (Females) 18 8620163 C CA RAB12 3e-07 985.0 6.4_gwama_inter_I_F_M_EUR 0 1.0138 Body mass index at 6-months, adj. for baseline saxagliptin European ancestry sex all European (All) 19 44509273 C CA ZNF230 3.1e-07 963.0 10.2.1_gmmat_all 0 1.0 Systolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 4 85201989 A G rs1967139 NKX6-1 3.1e-07 1474.0 12.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0054 Diastolic blood pressure at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 13 30074955 C G rs4997529 MTUS2 3.1e-07 995.0 15.1.1_mixedlm_EUR 0 0.97444 Estimated glomerular filtration rate, % change saxagliptin European ancestry all European (All) 7 147355237 T G rs28407127 CNTNAP2 3.1e-07 959.0 16.2.1_gmmat_all 0 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 14 93592961 C T rs12884185 ITPK1 3.1e-07 1492.0 5.1_gwama_inter_I_all_vs_C_all_EUR 0 1.0 Body mass index, % change both European ancestry treatment all European (All) 11 29285741 G A rs12800035 METTL15 3.1e-07 567.0 6.1.2_mixedlm_EUR 0 1.0224 Body mass index at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 12 25807308 C T rs6487504 LMNTD1 3.2e-07 516.0 1.2.1_mixedlm_EUR 0 1.0195 HbA1c, % change placebo European ancestry all European (All) 12 55101913 AT A DCD 3.2e-07 1456.0 16.1.2_gwama_inter_I_male_vs_C_males_all 0 0.97444 Estimated glomerular filtration rate at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 8 102660827 A C rs1892753 GRHL2 3.2e-07 985.0 5.4_gwama_inter_I_F_M_EUR 0 1.0313 Body mass index, % change saxagliptin European ancestry sex all European (All) 1 13959396 A G rs150459320 PDPN 3.3e-07 573.0 1.1.2_mixedlm_EUR 0 1.0027 HbA1c, % change saxagliptin European ancestry male European (Males) 1 47059527 GA G MKNK1 3.3e-07 526.0 11.2.1_mixedlm_EUR 0 1.0 Diastolic blood pressure, % change placebo European ancestry all European (All) 5 43237748 C A rs12108783 NIM1K 3.3e-07 898.0 9.2_gwama_inter_I_male_vs_C_males_EUR 0 1.0166 Systolic blood pressure, % change both European ancestry treatment male European (Males) 2 17823576 CTT C VSNL1 3.4e-07 846.0 1.1.3_gmmat_all 0 1.0 HbA1c, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 5 150920566 G A rs2288778 FAT2 3.4e-07 1776.0 3.1.1_gmmat_all 0 1.0 Fasting glucose, % change saxagliptin multi-ancestry all Multi-ancestry (All) 9 125377505 A G rs1329957 OR1Q1 3.4e-07 523.0 4.2.2_gmmat_all 0 1.0054 Fasting glucose at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 8 129133259 A G rs10956409 MYC 3.5e-07 849.0 14.1.3_gmmat_all 0 1.0 Heart rate at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 8 85194927 T TAAAAAG rs10639136 RALYL 3.5e-07 1777.0 15.1.1_gmmat_all 0 0.97444 Estimated glomerular filtration rate, % change saxagliptin multi-ancestry all Multi-ancestry (All) 18 2843337 C T rs60066182 EMILIN2 3.5e-07 521.0 16.2.2_gmmat_all 0 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 9 18799743 G GT ADAMTSL1 3.5e-07 421.0 18.2.2_gmmat_all 0 1.0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 16 81193156 C G rs10871403 GCSH 3.5e-07 516.0 4.2.1_mixedlm_EUR 0 1.011 Fasting glucose at 6-months, adj. for baseline placebo European ancestry all European (All) 3 124649519 C T rs10804566 MUC13 3.5e-07 1473.0 9.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0 Systolic blood pressure, % change both multi-ancestry treatment male Multi-ancestry (Males) 12 124876133 C T rs881290 NCOR2 3.6e-07 516.0 3.5_gwama_inter_C_F_M_EUR 0 1.0 Fasting glucose, % change placebo European ancestry sex all European (All) 10 7313253 C CAAA SFMBT2 3.6e-07 308.0 5.2.2_mixedlm_EUR 0 1.0166 Body mass index, % change placebo European ancestry male European (Males) 18 7174289 C T rs112941827 LAMA1 3.6e-07 686.0 7.1.1_gmmat_all 0 1.0 Weight, % change saxagliptin multi-ancestry all Multi-ancestry (All) 3 5955948 T A rs68087820 EDEM1 3.7e-07 438.0 15.2.3_gmmat_all 0 1.0 Estimated glomerular filtration rate, % change placebo multi-ancestry female Multi-ancestry (Females) 2 87561278 A AAAC IGKV3OR2-268 3.8e-07 1799.0 12.1.1_gmmat_all 0 1.0 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 4 3897630 G T rs60592225 ADRA2C 3.8e-07 1284.0 13.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Heart rate, % change both multi-ancestry treatment female Multi-ancestry (Females) 13 30074955 C G rs4997529 MTUS2 3.8e-07 420.0 15.1.3_mixedlm_EUR 0 1.0027 Estimated glomerular filtration rate, % change saxagliptin European ancestry female European (Females) 17 34485994 T G rs2522110 TBC1D3B 3.8e-07 303.0 7.1.2_mixedlm_EUR 0 1.1247 Weight, % change saxagliptin European ancestry male European (Males) 12 61787902 GA G TAFA2 3.9e-07 2733.0 1.1.1_gwama_inter_I_all_vs_C_all_all 0 1.011 HbA1c, % change both multi-ancestry treatment all Multi-ancestry (All) 3 193112917 C T rs12492813 ATP13A4 3.9e-07 1779.0 1.1.2_gwama_inter_I_F_M_all 0 1.0027 HbA1c, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) 9 29364521 A G rs2183833 LINGO2 3.9e-07 526.0 12.2.1_mixedlm_EUR 0 0.9298 Diastolic blood pressure at 6-months, adj. for baseline placebo European ancestry all European (All) 1 202778061 C T rs41302113 KDM5B 3.9e-07 521.0 15.2.2_gmmat_all 0 1.0 Estimated glomerular filtration rate, % change placebo multi-ancestry male Multi-ancestry (Males) 7 77529219 T A rs73375864 PHTF2 3.9e-07 2729.0 3.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0 Fasting glucose, % change both multi-ancestry treatment all Multi-ancestry (All) 2 49343112 G T rs17038288 FSHR 3.9e-07 1428.0 6.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0 Body mass index at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 19 14597524 CT C GIPC1 3.9e-07 663.0 7.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0054 Weight, % change both multi-ancestry treatment male Multi-ancestry (Males) 19 2904008 C T rs11673250 ZNF57 4e-07 527.0 10.2.2_gmmat_all 0 1.0054 Systolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 6 24474402 T C rs57950928 GPLD1 4e-07 1799.0 12.1.2_gwama_inter_I_F_M_all 0 1.0027 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 5 25894109 C G rs67975124 CDH9 4.1e-07 436.0 14.2.3_gmmat_all 0 1.0 Heart rate at 6-months, adj. for baseline placebo multi-ancestry female Multi-ancestry (Females) 3 124603071 GA G ITGB5 4.1e-07 2806.0 21.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0 Hypoglycemic events both multi-ancestry treatment all Multi-ancestry (All) 20 52418764 G A rs68186269 BCAS1 4.1e-07 960.0 9.2.2_gwama_inter_C_F_M_all 0 0.97444 Systolic blood pressure, % change placebo multi-ancestry sex all Multi-ancestry (All) 2 17823576 CTT C VSNL1 4.2e-07 1278.0 1.1.3_gwama_inter_I_females_vs_C_females_all 0 1.011 HbA1c, % change both multi-ancestry treatment female Multi-ancestry (Females) 1 22912914 C T rs183497128 EPHA8 4.3e-07 1798.0 11.1.1_gmmat_all 0 1.0 Diastolic blood pressure, % change saxagliptin multi-ancestry all Multi-ancestry (All) 15 82425034 G T rs112995593 EFL1 4.3e-07 424.0 11.1.3_mixedlm_EUR 0 1.0138 Diastolic blood pressure, % change saxagliptin European ancestry female European (Females) 13 91691565 C T rs4403919 GPC5 4.3e-07 521.0 16.2.1_mixedlm_EUR 0 1.0082 Estimated glomerular filtration rate at 6-months, adj. for baseline placebo European ancestry all European (All) 18 62158789 GCTA G SERPINB8 4.4e-07 840.0 3.1.3_gmmat_all 0 1.0054 Fasting glucose, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 14 40471111 GAT G rs35792573 FBXO33 4.4e-07 516.0 4.5_gwama_inter_C_F_M_EUR 0 1.0 Fasting glucose at 6-months, adj. for baseline placebo European ancestry sex all European (All) 1 67250214 T C rs79165225 TCTEX1D1 4.5e-07 1271.0 3.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Fasting glucose, % change both multi-ancestry treatment female Multi-ancestry (Females) 6 152396352 T C rs2747645 ESR1 4.6e-07 432.0 1.2.3_gmmat_all 0 1.0 HbA1c, % change placebo multi-ancestry female Multi-ancestry (Females) 3 194774716 T C rs2222146 XXYLT1 4.7e-07 525.0 11.2.2_gmmat_all 0 1.0054 Diastolic blood pressure, % change placebo multi-ancestry male Multi-ancestry (Males) 12 56503413 CA C PA2G4 4.7e-07 983.0 3.1.1_mixedlm_EUR 0 1.0 Fasting glucose, % change saxagliptin European ancestry all European (All) 20 42756127 C CT JPH2 4.8e-07 1472.0 11.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0 Diastolic blood pressure, % change both multi-ancestry treatment male Multi-ancestry (Males) 4 95103782 G T rs144228418 SMARCAD1 4.8e-07 1781.0 2.1.1_gmmat_all 0 1.0 HbA1c at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 1 109069552 G A rs147548658 FAM102B 4.9e-07 761.0 18.1.2_gmmat_all 0 1.0082 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 9 107661735 A G rs2777787 ABCA1 4.9e-07 1285.0 9.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Systolic blood pressure, % change both multi-ancestry treatment female Multi-ancestry (Females) 1 34477581 A G rs1325258 CSMD2 5e-07 933.0 1.1.2_gmmat_all 0 1.0027 HbA1c, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 6 19225294 G A rs9368049 ID4 5e-07 412.0 2.1.3_mixedlm_EUR 0 1.011 HbA1c at 6-months, adj. for baseline saxagliptin European ancestry female European (Females) 3 28513319 C T rs77511698 AC098650.1,ZCWPW2 5e-07 431.0 3.2.3_gmmat_all 0 1.0082 Fasting glucose, % change placebo multi-ancestry female Multi-ancestry (Females) 7 49621833 G A rs2886379 VWC2 5e-07 2677.0 6.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0054 Body mass index at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 6 16704690 G GAAGTAAGCCATAATT rs3841158 ATXN1 5e-07 2758.0 9.1.1_gwama_inter_I_all_vs_C_all_all 0 1.011 Systolic blood pressure, % change both multi-ancestry treatment all Multi-ancestry (All) 7 153610759 TG T rs11354017 DPP6 5.1e-07 1756.0 6.1.2_gwama_inter_I_F_M_all 0 1.0054 Body mass index at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 1 70252919 C T rs12064834 LRRC7 5.3e-07 848.0 13.1.3_gmmat_all 0 1.0 Heart rate, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 3 153505405 T G rs12636024 ARHGEF26 5.3e-07 418.0 5.1.3_mixedlm_EUR 0 1.0138 Body mass index, % change saxagliptin European ancestry female European (Females) 3 171109146 A G rs4894432 TNIK 5.4e-07 959.0 15.2.1_gmmat_all 0 1.0 Estimated glomerular filtration rate, % change placebo multi-ancestry all Multi-ancestry (All) 15 34516457 A AAAC rs71119950 EMC4 5.4e-07 612.0 2.3_gwama_inter_I_females_vs_C_females_EUR 0 1.0283 HbA1c at 6-months, adj. for baseline both European ancestry treatment female European (Females) 7 77741395 T C rs3807730 MAGI2 5.4e-07 851.0 9.1.3_gmmat_all 0 1.0 Systolic blood pressure, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 12 15736430 C A rs35677139 PTPRO 5.5e-07 507.0 5.2.1_mixedlm_EUR 0 1.0027 Body mass index, % change placebo European ancestry all European (All) 8 116866021 C A rs149982932 TRPS1 5.6e-07 1285.0 11.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Diastolic blood pressure, % change both multi-ancestry treatment female Multi-ancestry (Females) 15 91216772 C T rs369775258 CRTC3 5.6e-07 2761.0 12.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0054 Diastolic blood pressure at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 5 155348825 A G rs17053001 SGCD 5.6e-07 1287.0 12.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0027 Diastolic blood pressure at 6-months, adj. for baseline both multi-ancestry treatment female Multi-ancestry (Females) 3 194774716 T C rs2222146 XXYLT1 5.6e-07 526.0 12.2.2_gmmat_all 0 1.0027 Diastolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry male Multi-ancestry (Males) 2 236778064 T TAAA AGAP1 5.7e-07 1750.0 5.1.2_gwama_inter_I_F_M_all 0 1.0082 Body mass index, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) 22 46995841 G A rs138548 GRAMD4 5.8e-07 1287.0 10.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Systolic blood pressure at 6-months, adj. for baseline both multi-ancestry treatment female Multi-ancestry (Females) 1 244202434 T C rs1494122 ZBTB18 5.8e-07 526.0 14.2.1_mixedlm_EUR 0 1.0138 Heart rate at 6-months, adj. for baseline placebo European ancestry all European (All) 7 106119635 G A rs10232635 CCDC71L 5.8e-07 573.0 2.1.2_mixedlm_EUR 0 1.0054 HbA1c at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 12 7076236 G C rs2159887 PHB2 5.8e-07 921.0 6.2.2_gwama_inter_C_F_M_all 0 1.011 Body mass index at 6-months, adj. for baseline placebo multi-ancestry sex all Multi-ancestry (All) 19 38725570 G A rs12608912 DPF1 5.9e-07 207.0 10.2.3_mixedlm_EUR 0 1.0313 Systolic blood pressure at 6-months, adj. for baseline placebo European ancestry female European (Females) 19 32837429 C G rs4804990 ZNF507 6e-07 522.0 1.2.2_gmmat_all 0 1.0054 HbA1c, % change placebo multi-ancestry male Multi-ancestry (Males) 5 141070510 A G rs248607 ARAP3 6e-07 960.0 14.2.2_gwama_inter_C_F_M_all 0 1.0 Heart rate at 6-months, adj. for baseline placebo multi-ancestry sex all Multi-ancestry (All) 5 150554502 T G rs72790178 CCDC69 6e-07 1174.0 8.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0344 Weight at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 3 183301270 C G rs3860612 KLHL6 6.1e-07 349.0 17.2.3_gmmat_all 0 0.97444 Urine albumin-to-creatinine ratio, % change placebo multi-ancestry female Multi-ancestry (Females) 18 52367433 T C rs9950479 RAB27B 6.1e-07 516.0 2.5_gwama_inter_C_F_M_EUR 0 1.0 HbA1c at 6-months, adj. for baseline placebo European ancestry sex all European (All) 12 78963507 A ACTTTCGGAGG rs71441928 SYT1 6.2e-07 898.0 12.2_gwama_inter_I_male_vs_C_males_EUR 0 1.0313 Diastolic blood pressure at 6-months, adj. for baseline both European ancestry treatment male European (Males) 1 67134326 T C rs6692318 SGIP1 6.2e-07 616.0 4.3_gwama_inter_I_females_vs_C_females_EUR 0 1.0054 Fasting glucose at 6-months, adj. for baseline both European ancestry treatment female European (Females) 18 76733977 C G rs117015489 SALL3 6.5e-07 957.0 13.2.2_gwama_inter_C_F_M_all 0 1.0 Heart rate, % change placebo multi-ancestry sex all Multi-ancestry (All) 5 35238245 T C rs7710279 PRLR 6.6e-07 1499.0 3.1_gwama_inter_I_all_vs_C_all_EUR 0 1.0138 Fasting glucose, % change both European ancestry treatment all European (All) 9 127600299 G A rs7875034 WDR38 6.7e-07 851.0 11.1.3_gmmat_all 0 1.0 Diastolic blood pressure, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 1 44464654 A AGG SLC6A9 6.8e-07 985.0 1.1.1_mixedlm_EUR 0 1.011 HbA1c, % change saxagliptin European ancestry all European (All) 15 57162659 G C rs67278720 AC090517.4 6.9e-07 1182.0 17.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0 Urine albumin-to-creatinine ratio, % change both multi-ancestry treatment male Multi-ancestry (Males) 13 95615028 C CT ABCC4 6.9e-07 432.0 2.2.3_gmmat_all 0 1.0166 HbA1c at 6-months, adj. for baseline placebo multi-ancestry female Multi-ancestry (Females) 3 1256946 C T rs72999894 CNTN6 7e-07 579.0 14.1.2_mixedlm_EUR 0 1.0224 Heart rate at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 7 97473283 C T rs13230541 ASNS 7.1e-07 1782.0 16.1.2_gwama_inter_I_F_M_all 0 1.0027 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 2 51058745 T C rs10167695 NRXN1 7.1e-07 1414.0 18.1.1_gmmat_all 0 1.0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 12 25116659 G A rs145023972 BCAT1 7.1e-07 323.0 21.2.2_coxph_EUR 0 0.91006 Hypoglycemic events placebo European ancestry male European (Males) 11 88007909 C T rs10741358 CTSC 7.2e-07 844.0 15.1.3_gmmat_all 0 1.0 Estimated glomerular filtration rate, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 22 48444883 CT C TAFA5 7.2e-07 1246.0 5.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0027 Body mass index, % change both multi-ancestry treatment female Multi-ancestry (Females) 2 51381378 C G rs17041346 NRXN1 7.3e-07 954.0 2.2.2_gwama_inter_C_F_M_all 0 1.0 HbA1c at 6-months, adj. for baseline placebo multi-ancestry sex all Multi-ancestry (All) 10 33717091 AT A NRP1 7.3e-07 569.0 4.1.2_mixedlm_EUR 0 1.0138 Fasting glucose at 6-months, adj. for baseline saxagliptin European ancestry male European (Males) 10 68336295 T C rs10997242 CTNNA3 7.4e-07 947.0 11.1.2_gmmat_all 0 1.0 Diastolic blood pressure, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 4 126577457 TG T rs202110854 FAT4 7.5e-07 202.0 3.2.3_mixedlm_EUR 0 1.0224 Fasting glucose, % change placebo European ancestry female European (Females) 18 52886637 A T rs1787792 TCF4 7.6e-07 919.0 5.1.2_gmmat_all 0 1.0166 Body mass index, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 10 67930797 A G rs10740224 CTNNA3 7.7e-07 2741.0 16.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 1 181388963 T C rs10910933 CACNA1E 7.8e-07 450.0 17.1.2_mixedlm_EUR 0 1.1931 Urine albumin-to-creatinine ratio, % change saxagliptin European ancestry male European (Males) 7 94699936 C T rs12704777 PPP1R9A 7.9e-07 775.0 17.1.1_mixedlm_EUR 0 1.0054 Urine albumin-to-creatinine ratio, % change saxagliptin European ancestry all European (All) 18 35649470 G A rs7244286 CELF4 8e-07 851.0 12.1.3_gmmat_all 0 1.0 Diastolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 6 121081774 GATTT G rs67033980 TBC1D32 8.2e-07 1471.0 14.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0054 Heart rate at 6-months, adj. for baseline both multi-ancestry treatment male Multi-ancestry (Males) 4 119226291 C T rs200483108 PRSS12 8.3e-07 985.0 1.4_gwama_inter_I_F_M_EUR 0 1.0027 HbA1c, % change saxagliptin European ancestry sex all European (All) 3 152761474 T G rs17454914 RAP2B 8.4e-07 946.0 13.1.2_gmmat_all 0 1.0 Heart rate, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 12 27836249 C T rs11049094 PPFIBP1 8.4e-07 502.0 5.2.2_gmmat_all 0 1.0 Body mass index, % change placebo multi-ancestry male Multi-ancestry (Males) 5 41263324 G C rs10077836 C6 8.6e-07 953.0 3.2.2_gwama_inter_C_F_M_all 0 1.0082 Fasting glucose, % change placebo multi-ancestry sex all Multi-ancestry (All) 2 178141063 A G rs2364730 NFE2L2 8.6e-07 434.0 9.2.3_gmmat_all 0 0.97444 Systolic blood pressure, % change placebo multi-ancestry female Multi-ancestry (Females) X 43480664 A AAAAT MAOA 8.9e-07 917.0 5.2.2_gwama_inter_C_F_M_all 0 1.0027 Body mass index, % change placebo multi-ancestry sex all Multi-ancestry (All) 20 4438261 C T rs57698607 ADRA1D 9.2e-07 436.0 10.2.3_gmmat_all 0 0.97444 Systolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry female Multi-ancestry (Females) 18 62158789 GCTA G SERPINB8 9.2e-07 843.0 4.1.3_gmmat_all 0 1.0054 Fasting glucose at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) X 816862 T G rs5946507 ENSG00000185960.14_6 9.4e-07 983.0 4.1.1_mixedlm_EUR 0 1.0 Fasting glucose at 6-months, adj. for baseline saxagliptin European ancestry all European (All) 7 89450455 T C rs2373996 STEAP1 9.4e-07 2667.0 5.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0 Body mass index, % change both multi-ancestry treatment all Multi-ancestry (All) 15 101922323 A G rs1058260 PCSK6 9.4e-07 395.0 7.1.2_gmmat_all 0 1.011 Weight, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 13 101889517 C T rs9513874 NALCN 9.4e-07 1003.0 9.4_gwama_inter_I_F_M_EUR 0 1.0027 Systolic blood pressure, % change saxagliptin European ancestry sex all European (All) 12 129157292 C T rs11059821 TMEM132C 9.9e-07 811.0 7.1_gwama_inter_I_all_vs_C_all_EUR 0 1.0166 Weight, % change both European ancestry treatment all European (All) 17 76543801 G A rs8072446 DNAH17 1e-06 1799.0 10.1.1_gmmat_all 0 1.0 Systolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry all Multi-ancestry (All) 14 29969982 A G rs77989445 PRKD1 1e-06 1529.0 12.1_gwama_inter_I_all_vs_C_all_EUR 0 0.95116 Diastolic blood pressure at 6-months, adj. for baseline both European ancestry treatment all European (All) 6 121119504 T A rs2789072 TBC1D32 1e-06 898.0 14.2_gwama_inter_I_male_vs_C_males_EUR 0 1.0195 Heart rate at 6-months, adj. for baseline both European ancestry treatment male European (Males) 2 232250215 A AT ARMC9 1e-06 1516.0 16.1_gwama_inter_I_all_vs_C_all_EUR 0 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline both European ancestry treatment all European (All) 6 22289140 T C rs1205957 PRL 1e-06 1413.0 17.1.2_gwama_inter_I_F_M_all 0 0.97444 Urine albumin-to-creatinine ratio, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) 20 59395034 A G rs62198813 CDH4 1e-06 1414.0 18.1.2_gwama_inter_I_F_M_all 0 1.0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 18 32588720 C T rs12608431 MAPRE2 1e-06 507.0 5.5_gwama_inter_C_F_M_EUR 0 1.0195 Body mass index, % change placebo European ancestry sex all European (All) 7 80805175 T A rs1509911 SEMA3C 1.1e-06 2756.0 14.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0 Heart rate at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 9 75467061 G A rs61138465 TMC1 1.1e-06 1796.0 14.1.2_gwama_inter_I_F_M_all 0 1.0 Heart rate at 6-months, adj. for baseline saxagliptin multi-ancestry sex all Multi-ancestry (All) 4 84572978 G A rs72657228 GPAT3 1.1e-06 421.0 17.2.2_gmmat_all 0 1.0 Urine albumin-to-creatinine ratio, % change placebo multi-ancestry male Multi-ancestry (Males) 16 25068065 TAA T ARHGAP17 1.1e-06 2184.0 18.1.1_gwama_inter_I_all_vs_C_all_all 0 0.97444 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline both multi-ancestry treatment all Multi-ancestry (All) 6 164056181 A T rs12206892 QKI 1.1e-06 954.0 2.2.1_gmmat_all 0 1.011 HbA1c at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 14 25144436 C T rs8014126 GZMB 1.1e-06 526.0 9.2.2_gmmat_all 0 1.0 Systolic blood pressure, % change placebo multi-ancestry male Multi-ancestry (Males) 12 110244504 GA G TRPV4 1.2e-06 516.0 1.5_gwama_inter_C_F_M_EUR 0 1.0082 HbA1c, % change placebo European ancestry sex all European (All) 3 18299819 CT C TBC1D5 1.2e-06 652.0 17.1.3_gmmat_all 0 1.0 Urine albumin-to-creatinine ratio, % change saxagliptin multi-ancestry female Multi-ancestry (Females) 6 2470337 T C rs62391216 MYLK4 1.2e-06 770.0 17.2.1_gmmat_all 0 1.0027 Urine albumin-to-creatinine ratio, % change placebo multi-ancestry all Multi-ancestry (All) 7 1978508 G A rs551017625 AC069288.1,MAD1L1 1.2e-06 957.0 4.2.2_gwama_inter_C_F_M_all 0 1.0 Fasting glucose at 6-months, adj. for baseline placebo multi-ancestry sex all Multi-ancestry (All) 6 99802495 G A rs6912398 FAXC 1.2e-06 883.0 4.2_gwama_inter_I_male_vs_C_males_EUR 0 1.011 Fasting glucose at 6-months, adj. for baseline both European ancestry treatment male European (Males) 11 1644854 A G rs553789745 KRTAP5-4 1.3e-06 948.0 10.1.2_gmmat_all 0 1.0 Systolic blood pressure at 6-months, adj. for baseline saxagliptin multi-ancestry male Multi-ancestry (Males) 5 152766149 A G rs304849 GRIA1 1.3e-06 1777.0 15.1.2_gwama_inter_I_F_M_all 0 1.0082 Estimated glomerular filtration rate, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) 3 189396299 T C rs2378509 TP63 1.3e-06 1001.0 17.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Urine albumin-to-creatinine ratio, % change both multi-ancestry treatment female Multi-ancestry (Females) 2 105095539 C T rs76071636 POU3F3 1.3e-06 522.0 3.2.2_gmmat_all 0 1.0027 Fasting glucose, % change placebo multi-ancestry male Multi-ancestry (Males) 13 49458450 T C rs2407263 FNDC3A 1.4e-06 963.0 10.2.2_gwama_inter_C_F_M_all 0 1.0 Systolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry sex all Multi-ancestry (All) 9 9432198 G C rs60751932 PTPRD 1.4e-06 847.0 16.1.3_gmmat_all 0 1.0 Estimated glomerular filtration rate at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 3 160537315 C T rs723060 PPM1L 1.4e-06 761.0 17.1.2_gmmat_all 0 0.97444 Urine albumin-to-creatinine ratio, % change saxagliptin multi-ancestry male Multi-ancestry (Males) 2 71733531 G C rs10181951 DYSF 1.5e-06 1499.0 4.1_gwama_inter_I_all_vs_C_all_EUR 0 1.0054 Fasting glucose at 6-months, adj. for baseline both European ancestry treatment all European (All) 7 158287408 G A rs56249742 PTPRN2 1.5e-06 567.0 5.1.2_mixedlm_EUR 0 1.0283 Body mass index, % change saxagliptin European ancestry male European (Males) 12 126296181 C T rs7954415 TMEM132B 1.5e-06 832.0 6.1.3_gmmat_all 0 1.0027 Body mass index at 6-months, adj. for baseline saxagliptin multi-ancestry female Multi-ancestry (Females) 3 190543623 CCCTTCCTT C GMNC 1.6e-06 1285.0 14.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Heart rate at 6-months, adj. for baseline both multi-ancestry treatment female Multi-ancestry (Females) 17 11330291 G A rs16944711 SHISA6 1.6e-06 2736.0 15.1.1_gwama_inter_I_all_vs_C_all_all 0 0.97444 Estimated glomerular filtration rate, % change both multi-ancestry treatment all Multi-ancestry (All) 7 4389830 A G rs12538928 SDK1 1.6e-06 775.0 17.4_gwama_inter_I_F_M_EUR 0 1.1205 Urine albumin-to-creatinine ratio, % change saxagliptin European ancestry sex all European (All) 4 81312161 A G rs36190401 CFAP299 1.7e-06 1794.0 13.1.2_gwama_inter_I_F_M_all 0 1.0 Heart rate, % change saxagliptin multi-ancestry sex all Multi-ancestry (All) 22 41954940 CA C CSDC2 1.7e-06 960.0 14.2.1_gmmat_all 0 1.0027 Heart rate at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 1 39285553 G T rs1886690 RRAGC 1.8e-06 954.0 1.2.1_gmmat_all 0 1.0254 HbA1c, % change placebo multi-ancestry all Multi-ancestry (All) X 84890659 G GAA CHM 1.8e-06 898.0 13.2_gwama_inter_I_male_vs_C_males_EUR 0 1.0 Heart rate, % change both European ancestry treatment male European (Males) 3 165305924 T G rs372330305 BCHE 1.8e-06 1413.0 17.1.1_gmmat_all 0 1.0 Urine albumin-to-creatinine ratio, % change saxagliptin multi-ancestry all Multi-ancestry (All) 13 27616911 G A rs9579066 USP12 1.9e-06 1167.0 7.1.1_gwama_inter_I_all_vs_C_all_all 0 1.0 Weight, % change both multi-ancestry treatment all Multi-ancestry (All) 11 130700956 G A rs11222339 SNX19 2e-06 770.0 17.2.2_gwama_inter_C_F_M_all 0 0.97444 Urine albumin-to-creatinine ratio, % change placebo multi-ancestry sex all Multi-ancestry (All) 15 96670389 A G rs71396841 NR2F2 2e-06 936.0 3.1.2_gmmat_all 0 1.0027 Fasting glucose, % change saxagliptin multi-ancestry male Multi-ancestry (Males) X 116549794 C T rs5911802 KLHL13 2.2e-06 1467.0 13.1.2_gwama_inter_I_male_vs_C_males_all 0 1.0 Heart rate, % change both multi-ancestry treatment male Multi-ancestry (Males) 8 55915004 GT GTT XKR4 2.2e-06 917.0 5.2.1_gmmat_all 0 1.0 Body mass index, % change placebo multi-ancestry all Multi-ancestry (All) 4 39643904 GT G SMIM14 2.3e-06 983.0 4.4_gwama_inter_I_F_M_EUR 0 1.0054 Fasting glucose at 6-months, adj. for baseline saxagliptin European ancestry sex all European (All) 7 49621833 G A rs2886379 VWC2 2.4e-06 1249.0 6.1.3_gwama_inter_I_females_vs_C_females_all 0 1.0 Body mass index at 6-months, adj. for baseline both multi-ancestry treatment female Multi-ancestry (Females) 4 35254301 A AATATATATATATATATATATATAT ARAP2 2.7e-06 962.0 12.2.1_gmmat_all 0 1.0027 Diastolic blood pressure at 6-months, adj. for baseline placebo multi-ancestry all Multi-ancestry (All) 20 6703826 T C rs235762 BMP2 2.8e-06 1529.0 11.1_gwama_inter_I_all_vs_C_all_EUR 0 0.95116 Diastolic blood pressure, % change both European ancestry treatment all European (All) 4 39643904 GT G SMIM14 3e-06 983.0 3.4_gwama_inter_I_F_M_EUR 0 1.0054 Fasting glucose, % change saxagliptin European ancestry sex all European (All) 2 242021008 A AGG rs3085964 MTERF4,SNED1 3.8e-06 1529.0 9.1_gwama_inter_I_all_vs_C_all_EUR 0 1.3889 Systolic blood pressure, % change both European ancestry treatment all European (All) 1 244202434 T C rs1494122 ZBTB18 5.3e-06 1529.0 14.1_gwama_inter_I_all_vs_C_all_EUR 0 1.0224 Heart rate at 6-months, adj. for baseline both European ancestry treatment all European (All)