chrom pos ref alt rsids nearest_genes pval beta sebeta or maf af num_significant_in_peak phenostring phenocode peak arm cohort interaction participants category 8 1835801 T C rs12548513 ARHGEF10 9.1e-19 0.21 0.024 0.36 1 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 16 50757050 G GA NOD2 2.3e-11 0.22 0.033 0.41 1 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 6 40406829 C G rs4714345 LRFN2 1.3e-10 -0.43 0.067 0.092 8 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 10 50495309 CT C rs34473943 C10orf71 6.4e-10 0.061 2 Estimated glomerular filtration rate, % change 15.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 2 78755319 A G rs76822172 REG3G 1.1e-09 -1.0 0.17 0.051 3 Fasting glucose, % change 3.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 2 140888409 CT C rs564181702 LRP1B 1.6e-09 0.28 0.047 0.052 1 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 6 168124563 G T rs613631 AFDN 1.9e-09 -0.15 0.025 0.14 5 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 9 38383348 T C rs1543495 ALDH1B1 2.2e-09 0.18 0.029 0.11 1 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 4 28845073 A G rs67221275 STIM2 2.4e-09 0.34 0.056 0.23 13 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 12 127058590 C T rs74823582 TMEM132B 2.7e-09 -0.71 0.12 0.1 2 Estimated glomerular filtration rate, % change 15.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 7 12559831 T G rs10234141 AC013470.2 3.2e-09 2.2 0.37 9.1 0.072 0.072 5 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 6 51297371 CT CTT PKHD1 3.4e-09 0.091 1 HbA1c, % change 1.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 3 153505405 T G rs12636024 ARHGEF26 3.6e-09 -0.25 0.043 0.42 1 Body mass index, % change 5.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 3 152761474 T G rs17454914 RAP2B 4e-09 -0.41 0.07 0.11 0.11 24 Heart rate at 6-months, adj. for baseline 14.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 8101795 G C rs4631023 ABLIM2 4e-09 1.0 0.17 0.063 0.063 4 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 3 62726213 C G rs3846216 CADPS 5.6e-09 0.098 16 Body mass index, % change 5.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 4 67091414 C G rs546334151 EPHA5 6.5e-09 0.26 0.045 0.06 1 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 4 24505082 T C rs12644451 DHX15 7.3e-09 0.35 1 HbA1c, % change 1.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 4 177512854 T G rs1449739 VEGFC 7.3e-09 0.19 0.033 0.082 1 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 4 95601777 G A rs77007938 PDLIM5 8e-09 2.6 0.44 13.0 0.052 0.052 1 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 6 165126617 G A rs9356253 C6orf118 8.1e-09 0.099 1 HbA1c at 6-months, adj. for baseline 2.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 21 20181693 T G rs2156204 TMPRSS15 8.4e-09 -0.12 0.021 0.37 0.63 1 Heart rate, % change 13.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 99344266 C T rs62281788 COL8A1 8.5e-09 0.8 0.14 0.065 0.065 16 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 30699285 G A rs73213169 PCDH7 8.8e-09 0.86 0.15 0.057 0.057 2 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 3 53910117 G GA ACTR8 1e-08 0.11 17 Fasting glucose at 6-months, adj. for baseline 4.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 1 153258751 GAAGA G rs151285452 PGLYRP3 1.1e-08 -0.57 0.099 0.054 0.054 3 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 5 7519762 G A rs6867567 ADCY2 1.1e-08 -0.18 0.032 0.26 0.74 1 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 3 98622467 C T rs62278540 DCBLD2 1.1e-08 0.9 0.16 0.051 0.051 1 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 18 29789095 T G rs76393137 GAREM1,MEP1B 1.2e-08 -0.94 0.16 0.06 1 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 9 96359281 C T rs113617970 PHF2 1.2e-08 0.068 15 Diastolic blood pressure at 6-months, adj. for baseline 12.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 1 49065763 T G rs79907326 AGBL4 1.2e-08 -0.24 0.042 0.053 1 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) X 71138226 TA T rs11333019 NHSL2 1.3e-08 0.34 0.06 0.064 1 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 19 36662900 G A rs564429463 ZNF565 1.3e-08 1.1 0.19 0.051 0.051 6 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 16 49879988 G A rs35332951 ZNF423 1.4e-08 0.17 1 Body mass index at 6-months, adj. for baseline 6.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 3 101535208 G C rs35218344 NXPE3 1.4e-08 0.82 0.14 0.06 0.06 1 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 9 101208288 C A rs17770298 GABBR2 1.5e-08 0.42 0.074 0.096 0.096 6 Systolic blood pressure, % change 9.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 2 78675036 G T rs116632958 REG3G 1.8e-08 -0.55 0.098 0.1 1 Fasting glucose, % change 3.2.1_mixedlm_EUR True placebo European ancestry all European (All) 1 244836962 T G rs878964 DESI2 1.8e-08 0.89 0.16 0.05 0.05 1 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 28848381 C CT STIM2 1.9e-08 -0.35 0.063 0.3 2 Diastolic blood pressure, % change 11.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 17 522197 T C rs62056500 VPS53 1.9e-08 2.0 0.35 7.1 0.092 0.092 1 Hypoglycemic events 21.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 5 163393157 A G rs116794826 MAT2B 1.9e-08 0.21 0.037 0.064 3 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 17 59102007 G GT BCAS3 1.9e-08 1.1 0.19 0.051 0.051 1 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) X 71138226 TA T rs11333019 NHSL2 2e-08 0.39 0.069 0.076 1 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 21 26034093 C A rs2829239 MRPL39 2e-08 0.17 0.03 0.43 0.5700000000000001 1 Systolic blood pressure, % change 9.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) X 136490295 G A rs1209295 ZIC3 2.1e-08 0.19 0.034 0.05 1 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 1 72599680 A G rs77844954 NEGR1 2.2e-08 0.47 0.085 0.075 0.075 2 HbA1c at 6-months, adj. for baseline 2.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 19 5417355 C T rs10417465 ZNRF4 2.2e-08 0.83 0.15 0.057 0.057 1 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 14 80059956 G A rs112157272 NRXN3 2.3e-08 0.33 0.059 0.22 0.22 1 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 4 35096282 A T rs374103321 ARAP2 2.4e-08 0.31 0.056 0.19 1 Diastolic blood pressure, % change 11.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 6 165126617 G A rs9356253 C6orf118 2.5e-08 0.099 1 HbA1c, % change 1.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 2 159305479 G A rs1978403 CCDC148 2.6e-08 0.18 0.032 0.071 0.929 1 HbA1c at 6-months, adj. for baseline 2.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 4 28833274 C T rs2029669 STIM2 2.7e-08 0.3 2 Diastolic blood pressure at 6-months, adj. for baseline 12.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 21 23205367 T TC rs397959523 NCAM2 2.8e-08 -0.35 0.064 0.12 8 HbA1c at 6-months, adj. for baseline 2.2.1_mixedlm_EUR True placebo European ancestry all European (All) 9 752104 G T rs12002168 KANK1 2.8e-08 -0.37 0.067 0.23 0.23 1 Weight, % change 7.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 15 40635859 C T rs71472431 CCDC9B 3e-08 -0.58 0.1 0.06 1 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 4 147403735 G GA rs60347451 SLC10A7 3.2e-08 0.28 0.05 0.43 1 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 17 522197 T C rs62056500 VPS53 3.2e-08 1.4 0.25 0.091 1 Hypoglycemic events 21.2.1_coxph_EUR True placebo European ancestry all European (All) 20 31991141 CA C CDK5RAP1 3.3e-08 0.63 0.11 0.031 1 Diastolic blood pressure at 6-months, adj. for baseline 12.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 2 24628560 G C rs7590090 ITSN2 3.3e-08 2.1 0.38 8.1 0.072 0.072 1 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 14 31530164 C T rs35832522 AP4S1 3.3e-08 0.064 3 Weight at 6-months, adj. for baseline 8.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 8 8220441 T C rs71513189 PRAG1 3.4e-08 -0.51 0.093 0.11 1 HbA1c, % change 1.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 19 363083 G A rs73506546 THEG 3.5e-08 0.07 1 Diastolic blood pressure at 6-months, adj. for baseline 12.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 3 134373892 C T rs76219534 EPHB1 3.5e-08 1.9 0.35 6.9 0.058 0.058 1 Hypoglycemic events 21.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 1 209334346 C T rs139929618 CAMK1G 3.5e-08 1.0 0.18 0.055 0.055 2 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 17 56001553 G A rs150546082 CUEDC1 3.6e-08 -0.61 0.11 0.059 1 HbA1c at 6-months, adj. for baseline 2.2.1_mixedlm_EUR True placebo European ancestry all European (All) 2 201351188 G T rs17630975 KCTD18 3.6e-08 -0.76 0.14 0.057 1 Fasting glucose, % change 3.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 6 159126324 G A rs112845669 SYTL3 3.7e-08 -0.42 0.077 0.16 1 Systolic blood pressure at 6-months, adj. for baseline 10.2.1_mixedlm_EUR True placebo European ancestry all European (All) 20 5353790 CT C PROKR2 3.9e-08 0.26 1 Systolic blood pressure at 6-months, adj. for baseline 10.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 3 34885715 C CCA ARPP21 4.2e-08 -0.32 0.058 0.29 0.29 1 Heart rate at 6-months, adj. for baseline 14.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 10 97207044 G SORBS1 4.3e-08 -0.52 0.094 0.13 1 Fasting glucose at 6-months, adj. for baseline 4.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 5 25895231 CAAAA C rs35489945 CDH9 4.3e-08 1.0 0.18 0.051 0.051 1 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 6 10128271 G T rs10456848 TFAP2A 4.4e-08 0.21 1 Weight at 6-months, adj. for baseline 8.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 9 23368985 C A rs10965808 ELAVL2 4.5e-08 0.2 1 HbA1c at 6-months, adj. for baseline 2.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 3 66354122 T C rs10865666 SLC25A26 4.5e-08 -0.52 0.096 0.44 1 Body mass index, % change 5.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 21 25443530 C G rs13047570 MRPL39 4.5e-08 1.0 0.19 0.052 0.052 1 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 1 180616602 G A rs12128940 XPR1 4.6e-08 0.91 0.17 0.061 0.061 1 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 6 86851114 T A rs34580458 SYNCRIP 4.7e-08 1.7 0.31 5.5 0.22 0.22 1 Hypoglycemic events 21.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 4 35096282 A T rs374103321 ARAP2 4.8e-08 0.25 0.046 0.19 1 Diastolic blood pressure at 6-months, adj. for baseline 12.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 10 84830828 G A rs148008685 NRG3 4.8e-08 0.83 0.15 0.054 0.054 1 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 10 80020890 T C rs57004307 RPS24 5e-08 -0.75 0.14 0.055 0.055 0 Weight, % change 7.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 3 34885715 C CCA ARPP21 5.2e-08 -0.32 0.058 0.29 0.29 0 Heart rate, % change 13.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 14 97558285 AAAC A VRK1 5.2e-08 -0.21 0.038 0.41 0.41 0 Body mass index, % change 5.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 3 153505405 T G rs12636024 ARHGEF26 5.2e-08 -0.057 0.01 0.42 0 Body mass index at 6-months, adj. for baseline 6.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 9 32938475 C A rs10572454 APTX 5.5e-08 -0.2 0.037 0.056 0.944 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 12 67183423 CTATT C rs10535108 GRIP1 5.6e-08 0.39 0.071 0.46 0 HbA1c, % change 1.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 8 2476217 T C rs75568872 CSMD1 5.7e-08 -0.49 0.091 0.065 0.065 0 HbA1c at 6-months, adj. for baseline 2.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 3 28620674 C A rs140439414 AC098650.1,RBMS3 5.7e-08 1.0 0.19 0.052 0.052 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 12 69467073 G C rs7958303 CPM 5.9e-08 0.55 0 Diastolic blood pressure, % change 11.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 3 1256946 C T rs72999894 CNTN6 5.9e-08 0.41 0.076 0.098 0 Heart rate, % change 13.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 96967998 A T rs141250684 SDHAF3 6.1e-08 1.1 0.2 0.065 0 Heart rate, % change 13.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 10 86635236 C T rs138558907 CCSER2 6.1e-08 2.6 0.47 0.013 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 10 127841158 A T rs1674908 ADAM12 6.2e-08 0.5 0 HbA1c, % change 1.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 12 43632595 T G rs10880445 ADAMTS20 6.2e-08 0.16 0 HbA1c at 6-months, adj. for baseline 2.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 12 82126292 T TA PPFIA2 6.2e-08 0.2 0 Fasting glucose at 6-months, adj. for baseline 4.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 5 144775036 C T rs71592994 PRELID2 6.3e-08 -0.48 0.089 0.34 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 15 93786630 GAGAT G rs141016712 RGMA 6.3e-08 0.49 0.091 0.14 0 Heart rate, % change 13.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 5 150920566 G A rs2288778 FAT2 6.4e-08 0.17 0.032 0.27 0.27 0 Fasting glucose at 6-months, adj. for baseline 4.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 60169681 C T rs213423 FHIT 6.4e-08 0.74 0.14 0.056 0 Systolic blood pressure, % change 9.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 5 50475893 G A rs79125793 ISL1 6.5e-08 0.95 0.18 0.06 0.06 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 4 97586569 T C rs4576092 STPG2 6.6e-08 -0.44 0.081 0.27 0 Weight, % change 7.2.1_mixedlm_EUR True placebo European ancestry all European (All) 10 133460618 C T rs72853629 PPP2R2D 6.6e-08 0.58 0.11 0.064 0.064 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 134145835 G A rs62269517 ANAPC13 6.7e-08 0.74 0.14 0.068 0.068 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 8 16635861 A G rs58485217 MSR1 6.8e-08 0.075 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 3 60169681 C T rs213423 FHIT 6.9e-08 0.59 0.11 0.056 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 4 599688 G A rs56283233 PDE6B 7e-08 0.14 0 Fasting glucose, % change 3.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 3 101758986 G A rs151182177 ZPLD1 7e-08 0.77 0.14 0.062 0.062 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 11 134763958 G A rs4290245 B3GAT1 7.1e-08 -0.68 0.13 0.054 0 HbA1c at 6-months, adj. for baseline 2.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 7 141135114 G A rs10224927 TMEM178B 7.2e-08 -0.26 0.049 0.25 0.25 0 HbA1c at 6-months, adj. for baseline 2.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 7 220326 G A rs55712175 FAM20C 7.3e-08 0.3 0 Diastolic blood pressure at 6-months, adj. for baseline 12.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 4 128118705 G A rs77030524 INTU 7.4e-08 -0.54 0.1 0.052 0.052 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 2 80227984 C G rs636935 CTNNA2 7.5e-08 0.33 0.062 0.4 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 3 170360608 T C rs556346229 AC026316.4 7.8e-08 0.055 0 Diastolic blood pressure at 6-months, adj. for baseline 12.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 4 63103857 C T rs28626079 ADGRL3 7.9e-08 0.14 0.027 0.24 0.76 0 Body mass index at 6-months, adj. for baseline 6.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 10 39072082 A T rs144700372 LINC00999 8e-08 0.057 0 Weight at 6-months, adj. for baseline 8.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 2 47046581 CAA C SOCS5 8.1e-08 0.45 0.083 0.45 0 Urine albumin-to-creatinine ratio, % change 17.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 1 49071418 A G rs6702398 AGBL4 8.1e-08 -0.47 0.087 0.14 0 HbA1c at 6-months, adj. for baseline 2.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 18 46327155 G A rs76667091 CTIF 8.2e-08 0.055 0 Body mass index at 6-months, adj. for baseline 6.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) X 23408446 G GA PTCHD1 8.2e-08 0.8 0.15 0.057 0.057 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 11 117413071 A C rs533428 DSCAML1 8.3e-08 0.39 0.073 0.13 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.1_mixedlm_EUR True placebo European ancestry all European (All) 9 138899381 G GCA NACC2 8.3e-08 -1.2 0.22 0.31 0.43 0.5700000000000001 0 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 7 80805175 T A rs1509911 SEMA3C 8.4e-08 0.36 0 Heart rate, % change 13.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 7 55088578 T TA EGFR 8.4e-08 -0.41 0.076 0.17 0.17 0 Heart rate, % change 13.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 2 129205437 G A rs139440962 HS6ST1 8.4e-08 -0.69 0.13 0.061 0 Systolic blood pressure, % change 9.2.1_mixedlm_EUR True placebo European ancestry all European (All) X 95047839 CT C DIAPH2 8.5e-08 0.38 0.071 0.2 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 9 26156829 A C rs10967212 TUSC1 8.6e-08 0.69 0.13 0.076 0.076 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 13 55356303 T A rs9527268 OLFM4 8.7e-08 0.75 0.14 0.063 0.063 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 7 77742537 A C rs62461188 MAGI2 8.8e-08 0.26 0.048 0.25 0.25 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 20 55009147 A G rs735780 CASS4 8.8e-08 1.0 0.19 0.051 0.051 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 15 90412799 TAA T AP3S2,ARPIN-AP3S2 8.8e-08 0.45 0 Systolic blood pressure, % change 9.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 1 217089102 C A rs34783704 ESRRG 8.9e-08 0.075 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 11 20328070 A G rs11822785 HTATIP2 9e-08 0.21 0.04 0.055 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 8 76015011 C T rs62522790 CRISPLD1 9.1e-08 -0.22 0.042 0.052 0 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) 6 114339694 AT A HDAC2 9.3e-08 0.15 0.029 0.069 0.931 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 17 5555262 G A rs62075405 NLRP1 9.4e-08 0.058 0 Diastolic blood pressure at 6-months, adj. for baseline 12.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 13 23439359 T C rs79674500 SGCG 9.4e-08 0.79 0.15 0.057 0.057 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 6 11176034 G A rs9368603 NEDD9 9.5e-08 -0.38 0.071 0.12 0.12 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 11 97611132 T G rs117708534 CNTN5 9.5e-08 -0.58 0.11 0.076 0 Fasting glucose, % change 3.2.1_mixedlm_EUR True placebo European ancestry all European (All) 3 1256946 C T rs72999894 CNTN6 9.7e-08 0.52 0.098 0.1 0 Heart rate, % change 13.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 22 23916292 G A rs12169538 IGLL1 9.7e-08 0.81 0.15 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 1 16337252 C T rs1739836 SRARP 1e-07 0.13 0.024 0.079 0.921 0 Heart rate, % change 13.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 3 23819172 T C rs2168426 UBE2E1 1e-07 -0.17 0.032 0.46 0 HbA1c at 6-months, adj. for baseline 2.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 7805552 A G rs10085913 UMAD1 1e-07 0.4 0.075 0.17 0.17 0 HbA1c at 6-months, adj. for baseline 2.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) X 90305288 A C rs753932499 PABPC5 1e-07 -0.59 0.11 0.075 0 HbA1c at 6-months, adj. for baseline 2.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 5 153584363 A G rs4958711 GALNT10,MFAP3 1e-07 0.17 0.032 0.48 0.52 0 Body mass index at 6-months, adj. for baseline 6.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 13 26548451 A G rs4770890 ATP8A2 1e-07 -0.092 0.017 0.29 0 Body mass index at 6-months, adj. for baseline 6.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 8 102155823 C T rs112966235 ZNF706 1e-07 0.21 0.039 0.057 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 11 3098800 C T rs35134285 OSBPL5 1e-07 0.83 0.16 0.052 0.052 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 13 111305463 G A rs57095243 CARS2 1.1e-07 0.13 0 Diastolic blood pressure, % change 11.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 4 165374213 TA T MARCHF1 1.1e-07 0.25 0.048 0.33 0 Heart rate, % change 13.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 2 19682018 CATATATATATATATATATAT C OSR1 1.1e-07 -0.27 0.052 0.19 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 18 12235540 C T rs74917877 CIDEA 1.1e-07 0.13 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 9 28495767 A C rs10968617 LINGO2 1.1e-07 -0.28 0.052 0.19 0.19 0 Fasting glucose, % change 3.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 7 129397484 CA C NRF1 1.1e-07 0.093 0.018 0.078 0.922 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 7 74426130 G A rs144458482 CASTOR2 1.1e-07 -0.16 0.03 0.1 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 4 185258283 G T rs72701756 IRF2 1.1e-07 0.42 0.08 0.11 0.11 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 100801643 T C rs13096071 ABI3BP 1.1e-07 0.7 0.13 0.072 0.072 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 6 107020657 G T rs199529005 RTN4IP1 1.1e-07 0.81 0.15 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 3 101091192 T A rs34334124 SENP7 1.1e-07 0.75 0.14 0.063 0.063 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 7 220326 G A rs55712175 FAM20C 1.2e-07 0.56 0.11 0.29 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 5 84948547 A G rs10060598 COX7C 1.2e-07 0.64 0 HbA1c at 6-months, adj. for baseline 2.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 2 157022586 T C rs17187573 NR4A2 1.2e-07 0.052 0 HbA1c at 6-months, adj. for baseline 2.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 20 40314444 C G rs6129901 CHD6 1.2e-07 1.7 0.32 0.033 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 16 24455965 TA T rs371523491 CACNG3 1.2e-07 0.2 0 Fasting glucose, % change 3.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 2 201351188 G T rs17630975 KCTD18 1.2e-07 -0.61 0.12 0.057 0 Fasting glucose at 6-months, adj. for baseline 4.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 4 94766621 T C rs7693338 ATOH1 1.2e-07 -0.31 0.058 0.34 0.34 0 Fasting glucose at 6-months, adj. for baseline 4.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 2 85183070 G C rs148185493 KCMF1 1.2e-07 -0.7 0.13 0.057 0.057 0 Body mass index at 6-months, adj. for baseline 6.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 6 33525680 T C rs210170 BAK1 1.2e-07 0.1 0.019 0.35 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 3 190157542 A C rs9851374 TMEM207 1.2e-07 -0.39 0.074 0.34 0 Weight, % change 7.2.1_mixedlm_EUR True placebo European ancestry all European (All) 7 134901282 TAC T rs71174507 WDR91 1.2e-07 0.093 0 Weight at 6-months, adj. for baseline 8.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 12 130781878 T C rs10466889 PIWIL1 1.3e-07 -0.31 0.059 0.37 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 1 17240551 TCCCCGCCCCGTGGCGGGGACG T rs150160215 CROCC 1.3e-07 0.49 0 Systolic blood pressure at 6-months, adj. for baseline 10.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 3 152833810 G A rs56107526 RAP2B 1.3e-07 -0.27 0.051 0.11 0.11 0 Heart rate at 6-months, adj. for baseline 14.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) X 84615532 GTA G POF1B 1.3e-07 0.27 0.051 0.29 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 8 137802025 C T rs71530187 KHDRBS3 1.3e-07 -0.42 0.08 0.12 0 Fasting glucose, % change 3.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 1 49065763 T G rs79907326 AGBL4 1.3e-07 -0.89 0.17 0.053 0 Weight, % change 7.2.1_mixedlm_EUR True placebo European ancestry all European (All) 11 100929187 C T rs1144133 PGR 1.3e-07 0.18 0.034 0.077 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 15 90412799 TAA T AP3S2,ARPIN-AP3S2 1.4e-07 0.45 0 Systolic blood pressure at 6-months, adj. for baseline 10.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 5 135028007 C CA SLC25A48 1.4e-07 -0.31 0.06 0.32 0.32 0 Diastolic blood pressure, % change 11.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 1 153265396 G C rs67401364 PGLYRP3 1.4e-07 -0.49 0.093 0.061 0.061 0 Estimated glomerular filtration rate, % change 15.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 12 84541558 C CT SLC6A15 1.4e-07 0.7 0 Estimated glomerular filtration rate, % change 15.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 2 232250398 G T rs7594399 ARMC9 1.4e-07 -0.44 0.084 0.056 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 2 12786284 A G rs35855677 TRIB2 1.4e-07 -0.19 0.037 0.49 0.49 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 14 26872445 G A rs6574949 NOVA1 1.4e-07 -0.13 0.025 0.15 0.85 0 HbA1c at 6-months, adj. for baseline 2.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 19 847944 A G PRTN3 1.4e-07 -2.4 0.45 0.013 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 20 62594247 G A rs2275294 ZNF512B 1.4e-07 1.1 0.22 0.26 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 2 105063075 T G rs73946460 POU3F3 1.4e-07 0.066 0 Fasting glucose, % change 3.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 2 2594300 C T rs72773013 MYT1L 1.4e-07 0.21 0.04 0.06 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 4 67091414 C G rs546334151 EPHA5 1.4e-07 0.77 0.15 0.058 0.058 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 6 114687009 A T rs190151981 HS3ST5 1.4e-07 0.93 0.18 0.06 0.06 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 12 99215691 C CT ANKS1B 1.5e-07 0.2 0.039 0.35 0.35 0 Diastolic blood pressure, % change 11.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 4 28833274 C T rs2029669 STIM2 1.5e-07 0.3 0 Diastolic blood pressure, % change 11.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 3 120250293 T G rs1982187 NDUFB4 1.5e-07 0.082 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 6 22980272 A G rs2473686 HDGFL1 1.5e-07 -1.3 0.24 0.28 0.46 0.54 0 Hypoglycemic events 21.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 5 159045869 G A rs6874625 ADRA1B 1.5e-07 -0.16 0.03 0.31 0.31 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 145284477 G GTATCTATC PLOD2 1.5e-07 -0.8 0.15 0.051 0.051 0 Body mass index at 6-months, adj. for baseline 6.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 5 145228588 T C rs6860802 GRXCR2 1.5e-07 0.47 0.09 0.09 0.09 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 6 137812161 C T rs6918078 OLIG3 1.5e-07 0.77 0.15 0.058 0.058 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 18 7381988 TG T rs139635294 LRRC30 1.5e-07 0.93 0.18 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 7 3800135 C T rs62437938 SDK1 1.5e-07 0.93 0.18 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 5 18475117 C T rs138898898 H3Y1 1.5e-07 0.97 0.19 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 4 159381989 C A rs936091 RXFP1 1.5e-07 0.34 0 Systolic blood pressure, % change 9.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 17 67234789 T C rs74843023 ABCA10 1.6e-07 -0.6 0.12 0.065 0 Diastolic blood pressure, % change 11.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 15 40635859 C T rs71472431 CCDC9B 1.6e-07 -0.88 0.17 0.06 0 Estimated glomerular filtration rate, % change 15.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 5 180583043 T A rs34945347 OR2V2 1.6e-07 -0.45 0.086 0.073 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 1 160613894 C T rs41463446 SLAMF1 1.6e-07 -0.32 0.061 0.14 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 4 95601777 G A rs77007938 PDLIM5 1.6e-07 1.8 0.34 5.9 0.054 0.054 0 Hypoglycemic events 21.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 6 130027764 G C rs9375657 ARHGAP18 1.6e-07 1.3 0.26 0.058 0 Hypoglycemic events 21.2.1_coxph_EUR True placebo European ancestry all European (All) 4 127707034 G A rs79748898 INTU 1.6e-07 -0.52 0.099 0.054 0.054 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 21 41332464 C T rs74518163 PCP4 1.6e-07 -0.63 0.12 0.13 0.13 0 Weight, % change 7.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 8 102616732 G A rs17399841 GRHL2 1.6e-07 0.82 0.16 0.052 0.052 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 17 58084324 A G rs7222369 AC005702.1 1.6e-07 0.98 0.19 0.053 0.053 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 6 136551731 T A rs72975549 MTFR2 1.6e-07 -0.41 0.078 0.087 0.087 0 Systolic blood pressure, % change 9.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 1 85172587 C A rs79075460 SSX2IP 1.6e-07 -1.1 0.21 0.058 0 Systolic blood pressure, % change 9.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 6 129418710 G A rs7772780 LAMA2 1.7e-07 0.06 0 Systolic blood pressure at 6-months, adj. for baseline 10.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 2 232250215 A AT ARMC9 1.7e-07 0.058 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 8 16636406 C G rs7828765 MSR1 1.7e-07 -0.45 0.087 0.071 0.071 0 HbA1c at 6-months, adj. for baseline 2.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 3 124551967 C T rs4141663 ITGB5 1.7e-07 0.41 0 Hypoglycemic events 21.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) X 70621851 A G rs28382184 TAF1 1.7e-07 0.06 0 Fasting glucose, % change 3.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 1 230616852 T A rs200161 PGBD5 1.7e-07 0.15 0.029 0.36 0.64 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 12 93752393 C T rs73223234 NUDT4 1.7e-07 -0.27 0.051 0.21 0.21 0 Body mass index at 6-months, adj. for baseline 6.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 4 154931179 C A rs13105395 SFRP2 1.7e-07 0.4 0.076 0.22 0.22 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) X 130892672 G C rs143393674 IGSF1 1.8e-07 -0.6 0.12 0.052 0 HbA1c, % change 1.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 14 49965653 AT A RPS29 1.8e-07 -0.5 0.096 0.28 0 Heart rate, % change 13.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 19 17505859 C T rs8102244 CCDC194 1.8e-07 0.72 0 Estimated glomerular filtration rate, % change 15.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 3 2483305 G A rs2648694 CNTN4 1.8e-07 0.35 0 Urine albumin-to-creatinine ratio, % change 17.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 5 85010377 T A rs7729979 COX7C 1.8e-07 0.16 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 7 147755391 A G rs6971366 CNTNAP2 1.8e-07 0.16 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 22 34733178 T C rs5999301 LARGE1 1.8e-07 -0.19 0.036 0.41 0.41 0 Body mass index at 6-months, adj. for baseline 6.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) X 25036756 T TTATA ARX 1.8e-07 -0.65 0.12 0.064 0.064 0 Body mass index at 6-months, adj. for baseline 6.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 3 3254752 A G rs73111317 CRBN 1.8e-07 -0.21 0.04 0.073 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 7 9213427 A G rs13312215 NXPH1 1.8e-07 -0.14 0.028 0.05 0.95 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 16 49683528 A C rs2216059 ZNF423 1.8e-07 0.25 0.048 0.32 0 Systolic blood pressure, % change 9.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 4 110683345 T TAAAA AC126283.1,CFI 1.9e-07 0.9 0 HbA1c, % change 1.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 6 159610904 T C rs409096 FNDC1 1.9e-07 -0.38 0.074 0.18 0 Heart rate, % change 13.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 9 7468164 C A rs16926157 KDM4C 1.9e-07 0.19 0.037 0.063 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 6 32489745 C G rs41548618 HLA-DRB5 1.9e-07 0.38 0.073 0.15 0 Systolic blood pressure, % change 9.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 5 43231984 TC T rs78014759 NIM1K 1.9e-07 -0.36 0.069 0.27 0 Systolic blood pressure, % change 9.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 15 45719187 G C rs17536527 C15orf48 2e-07 -0.12 0.023 0.46 0.54 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 5 84937488 G C rs200536374 COX7C 2e-07 0.41 0.078 0.19 0.19 0 Fasting glucose at 6-months, adj. for baseline 4.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 7 55739193 C G rs77753751 VOPP1 2e-07 -0.14 0.026 0.13 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 2 150203864 G T rs80012003 LYPD6 2e-07 0.52 0.1 0.072 0.072 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) X 25663697 C T rs779711156 MAGEB18 2e-07 0.19 0.037 0.082 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) X 142458627 G A rs142089546 SPANXN3 2e-07 0.67 0.13 0.076 0.076 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 11 87832124 AT A rs34069232 RAB38 2e-07 -0.19 0.037 0.063 0 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) 3 28943138 T G rs73058090 AC098650.1,RBMS3 2.1e-07 0.57 0.11 0.16 0 HbA1c, % change 1.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 1 86004817 T G rs1882936 DDAH1 2.1e-07 0.49 0 Systolic blood pressure at 6-months, adj. for baseline 10.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 5 66170532 T C rs16895768 MAST4 2.1e-07 0.18 0 Diastolic blood pressure, % change 11.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 6 112354506 TA T rs113549768 CCN6 2.1e-07 0.81 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 12 84209697 C T rs9943848 TMTC2 2.1e-07 -0.38 0.072 0.054 0.054 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 11 116493950 T G rs1240659 BUD13 2.1e-07 -0.21 0.041 0.17 0.17 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 6 136978261 C A rs61495120 MAP3K5 2.1e-07 0.52 0.099 0.13 0.13 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 17 81038570 C CG rs201014210 METRNL 2.1e-07 0.95 0.18 0.056 0.056 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 10 125258415 C T rs705167 GPR26 2.2e-07 -0.21 0.041 0.45 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 10 1447105 G T rs11250496 ADARB2 2.2e-07 0.41 0.08 0.18 0.18 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 21 19060457 T G rs150303942 BTG3 2.2e-07 -0.53 0.1 0.057 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 12 82126292 T TA PPFIA2 2.2e-07 0.28 0.053 0.18 0.18 0 Fasting glucose at 6-months, adj. for baseline 4.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 11 120718086 T A rs11218029 GRIK4 2.2e-07 -0.91 0.18 0.099 0 Body mass index, % change 5.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 17 54508441 C G rs11653578 ANKFN1 2.2e-07 -0.18 0.034 0.24 0.24 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 7 93426208 A G rs62464049 GNGT1 2.2e-07 0.75 0.15 0.06 0.06 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 7 100396900 C T rs61320564 ZAN 2.2e-07 0.89 0.17 0.063 0.063 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 14 90897728 GTT GTTT rs529841721 CALM1 2.2e-07 0.85 0.16 0.07 0.07 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 10 2050303 G A rs35168688 ADARB2 2.3e-07 0.13 0 HbA1c, % change 1.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 5 43241942 C T rs9292867 NIM1K 2.3e-07 0.28 0 Systolic blood pressure at 6-months, adj. for baseline 10.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 7 141122364 G C rs6464447 TMEM178B 2.3e-07 0.34 0 Heart rate, % change 13.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 15 70925726 C T rs12904891 UACA 2.3e-07 -0.43 0.083 0.23 0 Heart rate at 6-months, adj. for baseline 14.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 7 103366870 C G rs565901 RELN 2.3e-07 0.89 0 HbA1c at 6-months, adj. for baseline 2.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 14 84056558 C CAA FLRT2 2.3e-07 0.28 0.055 0.32 0.32 0 HbA1c at 6-months, adj. for baseline 2.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 8 2918034 C A rs75442393 CSMD1 2.3e-07 -0.69 0.13 0.068 0.068 0 Body mass index at 6-months, adj. for baseline 6.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 7 67431142 G T rs75236059 TYW1 2.3e-07 0.8 0.15 0.053 0.053 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 10 86300986 T C rs1777121 CCSER2 2.3e-07 -0.19 0.036 0.054 0.946 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 3 194766665 C T rs7639502 XXYLT1 2.4e-07 0.28 0.055 0.28 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 6 33526951 T C rs183300 BAK1 2.4e-07 0.35 0 Body mass index at 6-months, adj. for baseline 6.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 8 58183963 C CT BPNT2 2.4e-07 0.33 0.065 0.17 0.17 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 2 53841210 A G rs7575736 ASB3 2.4e-07 -0.18 0.036 0.1 0 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) 6 24474402 T C rs57950928 GPLD1 2.5e-07 -0.42 0.081 0.08 0.08 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 3 194774716 T C rs2222146 XXYLT1 2.5e-07 0.87 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) X 90305288 A C rs753932499 PABPC5 2.5e-07 -0.48 0.094 0.072 0 HbA1c at 6-months, adj. for baseline 2.2.1_mixedlm_EUR True placebo European ancestry all European (All) 7 139175551 C A rs7777713 KLRG2 2.5e-07 -0.3 0.059 0.15 0 Body mass index, % change 5.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 12 5085416 C T rs4766320 KCNA1 2.5e-07 -0.16 0.03 0.44 0.56 0 Systolic blood pressure, % change 9.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 1 110962800 T G rs3893159 LAMTOR5 2.6e-07 -0.24 0.046 0.5 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 7 148327260 A G rs713590 C7orf33 2.6e-07 0.065 0 Diastolic blood pressure, % change 11.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) X 84615532 GTA G POF1B 2.6e-07 0.29 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 4 8515318 A G rs7683947 TRMT44 2.6e-07 0.85 0 Urine albumin-to-creatinine ratio, % change 17.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 7 3814802 G A rs74349337 SDK1 2.6e-07 1.6 0.31 0.038 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 7 158314218 C T rs10259438 PTPRN2 2.6e-07 0.33 0.064 0.48 0 Weight, % change 7.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 5 31717578 A G rs71627321 PDZD2 2.6e-07 0.79 0.15 0.053 0.053 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 14 82563262 C A rs116895642 SEL1L 2.6e-07 0.086 0 Weight at 6-months, adj. for baseline 8.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 1 22912914 C T rs183497128 EPHA8 2.6e-07 0.37 0.071 0.055 0.055 0 Systolic blood pressure, % change 9.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 192764993 G C rs7653679 MB21D2 2.6e-07 -0.4 0.078 0.39 0 Systolic blood pressure, % change 9.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 14 21946535 A G rs12435421 TOX4 2.7e-07 0.49 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 6 36745580 A G rs12209686 CPNE5 2.7e-07 0.34 0.066 0.17 0.17 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 6 51297371 CT CTT PKHD1 2.7e-07 0.093 0 HbA1c at 6-months, adj. for baseline 2.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 1 239155348 T A rs76747138 CHRM3 2.7e-07 -0.55 0.11 0.1 0 Fasting glucose at 6-months, adj. for baseline 4.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 7 158276926 C T rs7810884 PTPRN2 2.7e-07 0.25 0.049 0.25 0 Body mass index, % change 5.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 5 150554502 T G rs72790178 CCDC69 2.7e-07 0.077 0 Weight at 6-months, adj. for baseline 8.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 9 126344742 G A rs7047006 DENND1A 2.7e-07 0.95 0.18 0.055 0.055 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 17 36676018 C T rs60486271 ARHGAP23 2.7e-07 0.93 0.18 0.057 0.057 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 4 95103782 G T rs144228418 SMARCAD1 2.8e-07 0.35 0.068 0.061 0.061 0 HbA1c, % change 1.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 2 48322221 C T rs12469601 FBXO11 2.8e-07 0.26 0 HbA1c, % change 1.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 1 110907121 CTT C SLC16A4 2.8e-07 0.47 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 11 61277885 G A rs10897165 LRRC10B 2.8e-07 -0.39 0.077 0.12 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) X 172929 T C rs28698141 ENSG00000182378.15_10 2.8e-07 -0.2 0.04 0.27 0.73 0 Heart rate, % change 13.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 1 177494053 GA G rs10716131 BRINP2 2.8e-07 -0.23 0.044 0.26 0 Heart rate at 6-months, adj. for baseline 14.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 11 78627549 A G rs116941471 TENM4 2.8e-07 2.5 0.49 0.012 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 18 7434765 C T rs12373198 PTPRM 2.8e-07 -0.2 0.038 0.18 0.8200000000000001 0 Body mass index, % change 5.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 22 45953057 A C rs134817 FBLN1 2.8e-07 -0.22 0.042 0.067 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 2 220788294 C G rs72955832 SLC4A3 2.8e-07 0.75 0.15 0.059 0.059 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 10 80020890 T C rs57004307 RPS24 2.8e-07 -0.71 0.14 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 3 109453564 C CA DPPA4 2.8e-07 0.39 0 Systolic blood pressure, % change 9.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 10 68355089 TTTA T CTNNA3 2.9e-07 0.19 0 Diastolic blood pressure, % change 11.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 7 20538382 G T rs73072690 ITGB8 2.9e-07 0.14 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 3 16886204 G A rs115500941 PLCL2 2.9e-07 -0.44 0.085 0.076 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 19 56795496 G A rs8104696 EDDM13,ZSCAN5A 2.9e-07 0.79 0 Fasting glucose at 6-months, adj. for baseline 4.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 22 31051450 G A rs201087159 DUSP18,SLC35E4 2.9e-07 0.2 0 Body mass index, % change 5.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 2 237608300 G A rs7566491 ACKR3 2.9e-07 0.73 0.14 0.085 0.085 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 2 74116635 CT C rs11364899 ACTG2 3e-07 0.081 0 HbA1c, % change 1.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 12 20240325 C T rs2579265 PDE3A 3e-07 0.938 0 Diastolic blood pressure, % change 11.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 3 43981374 C A rs11130018 ABHD5 3e-07 -0.28 0.055 0.39 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 2 206736071 C T rs76282090 NRP2 3e-07 -0.72 0.14 0.087 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 12 10561279 C G rs2617171 KLRC4,KLRC4-KLRK1 3e-07 0.32 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 12 95206627 C A rs10745700 NDUFA12 3e-07 -0.31 0.061 0.42 0 HbA1c at 6-months, adj. for baseline 2.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 7 147755391 A G rs6971366 CNTNAP2 3e-07 0.16 0 Fasting glucose, % change 3.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 12 20218444 T A rs5796847 PDE3A 3e-07 -0.1 0.02 0.32 0.6799999999999999 0 Body mass index, % change 5.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 4 54170130 G A rs13102168 SCFD2 3e-07 0.32 0 Body mass index, % change 5.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 17 16700193 CTT C AC098850.3 3e-07 -0.18 0.035 0.11 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 18 8620163 C CA RAB12 3e-07 0.48 0 Body mass index at 6-months, adj. for baseline 6.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 5 162743572 T C rs142395214 CCNG1 3e-07 0.21 0.041 0.071 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 15 87432014 G A rs4887515 AGBL1 3e-07 -0.22 0.043 0.083 0.917 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 12 73021627 A AT TRHDE 3e-07 0.13 0 Systolic blood pressure, % change 9.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 4 152782099 C T rs570426 GATB 3.1e-07 0.52 0.1 0.069 0 HbA1c, % change 1.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 19 44509273 C CA ZNF230 3.1e-07 0.13 0.026 0.24 0.76 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 4 85201989 A G rs1967139 NKX6-1 3.1e-07 0.089 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 13 30074955 C G rs4997529 MTUS2 3.1e-07 0.34 0.066 0.13 0 Estimated glomerular filtration rate, % change 15.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 147355237 T G rs28407127 CNTNAP2 3.1e-07 0.39 0.076 0.089 0.089 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 13 87039360 T C rs13313345 SLITRK6 3.1e-07 -0.43 0.085 0.16 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 14 93592961 C T rs12884185 ITPK1 3.1e-07 0.23 0 Body mass index, % change 5.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 7 158276926 C T rs7810884 PTPRN2 3.1e-07 0.06 0.012 0.25 0 Body mass index at 6-months, adj. for baseline 6.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 11 29285741 G A rs12800035 METTL15 3.1e-07 -0.15 0.029 0.056 0 Body mass index at 6-months, adj. for baseline 6.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 17 43461225 T C rs12939168 ARHGAP27 3.1e-07 0.69 0.13 0.07 0.07 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 12 25807308 C T rs6487504 LMNTD1 3.2e-07 0.35 0.068 0.15 0 HbA1c, % change 1.2.1_mixedlm_EUR True placebo European ancestry all European (All) 4 167587657 G A rs138143060 SPOCK3 3.2e-07 0.29 0.057 0.086 0.086 0 Heart rate at 6-months, adj. for baseline 14.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 12 55101913 AT A DCD 3.2e-07 0.074 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 1 64273591 A G rs659592 ROR1 3.2e-07 0.071 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 8 102660827 A C rs1892753 GRHL2 3.2e-07 0.23 0 Body mass index, % change 5.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 10 6614332 T C rs2007252 PRKCQ 3.2e-07 0.39 0 Body mass index at 6-months, adj. for baseline 6.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 17 10829381 A G rs565351094 PIRT 3.2e-07 -0.19 0.037 0.061 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 17 58571005 CT C rs551786086 APPBP2 3.2e-07 0.93 0.18 0.056 0.056 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 12 43638441 AT A ADAMTS20 3.3e-07 0.16 0.031 0.29 0.29 0 HbA1c, % change 1.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 1 13959396 A G rs150459320 PDPN 3.3e-07 0.42 0.082 0.095 0 HbA1c, % change 1.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 1 47059527 GA G MKNK1 3.3e-07 0.38 0.074 0.26 0 Diastolic blood pressure, % change 11.2.1_mixedlm_EUR True placebo European ancestry all European (All) 7 2939221 T TG CARD11 3.3e-07 0.34 0 HbA1c at 6-months, adj. for baseline 2.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 12 15736430 C A rs35677139 PTPRO 3.3e-07 0.27 0 Body mass index, % change 5.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 10 84609294 ATTGT A rs144738961 NRG3 3.3e-07 0.21 0.04 0.058 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) X 142458627 G A rs142089546 SPANXN3 3.3e-07 0.17 0.034 0.062 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 10 106314843 TA T SORCS3 3.3e-07 0.92 0.18 0.057 0.057 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 5 50852537 A G rs3040115 ISL1 3.3e-07 0.86 0.17 0.065 0.065 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 1 183834662 G A rs112946957 RGL1 3.3e-07 0.7 0.14 0.03 0 Systolic blood pressure, % change 9.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 16 26958361 G A rs9923933 C16orf82 3.3e-07 -1.3 0.25 0.061 0 Systolic blood pressure, % change 9.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 5 43237748 C A rs12108783 NIM1K 3.3e-07 0.28 0 Systolic blood pressure, % change 9.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 2 17823576 CTT C VSNL1 3.4e-07 0.44 0.087 0.078 0.078 0 HbA1c, % change 1.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 5 150920566 G A rs2288778 FAT2 3.4e-07 0.16 0.032 0.27 0.27 0 Fasting glucose, % change 3.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 5 90008988 A T rs10060365 ADGRV1 3.4e-07 0.5700000000000001 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 9 125377505 A G rs1329957 OR1Q1 3.4e-07 -0.16 0.032 0.078 0.922 0 Fasting glucose at 6-months, adj. for baseline 4.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 6 10580848 T TA GCNT2 3.4e-07 0.13 0 Body mass index, % change 5.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 12 126295083 G A rs7313371 TMEM132B 3.4e-07 -0.14 0.028 0.36 0.36 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 14 62000170 A G rs12587495 AL355916.3,PRKCH 3.4e-07 0.15 0.029 0.05 0 Body mass index at 6-months, adj. for baseline 6.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 14 26237585 G A rs75451321 NOVA1 3.4e-07 0.96 0.19 0.052 0.052 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 19 43764501 T G rs11666051 PSG9 3.4e-07 0.53 0.1 0.25 0 Systolic blood pressure, % change 9.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 1 235095183 G A rs7531062 TOMM20 3.5e-07 0.34 0 Heart rate, % change 13.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 8 129133259 A G rs10956409 MYC 3.5e-07 -0.19 0.038 0.4 0.4 0 Heart rate at 6-months, adj. for baseline 14.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 8 85194927 T TAAAAAG rs10639136 RALYL 3.5e-07 0.11 0.021 0.38 0.62 0 Estimated glomerular filtration rate, % change 15.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 4 165709614 C CT rs11376212 SMIM31 3.5e-07 -0.2 0.04 0.44 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 18 2843337 C T rs60066182 EMILIN2 3.5e-07 -0.4 0.078 0.16 0.16 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 5 1063907 A C rs576240314 SLC12A7 3.5e-07 -0.4 0.079 0.16 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 5 174687705 C T rs62390589 DRD1 3.5e-07 -0.42 0.082 0.16 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 9 18799743 G GT ADAMTSL1 3.5e-07 -0.74 0.15 0.056 0.056 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 16 81193156 C G rs10871403 GCSH 3.5e-07 0.27 0.053 0.43 0 Fasting glucose at 6-months, adj. for baseline 4.2.1_mixedlm_EUR True placebo European ancestry all European (All) 3 124649519 C T rs10804566 MUC13 3.5e-07 0.9 0 Systolic blood pressure, % change 9.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 22 22613242 T G rs5757698 VPREB1 3.6e-07 0.41 0.08 0.43 0 HbA1c, % change 1.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 12 124876133 C T rs881290 NCOR2 3.6e-07 0.23 0 Fasting glucose, % change 3.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 10 7313253 C CAAA SFMBT2 3.6e-07 -0.53 0.1 0.17 0 Body mass index, % change 5.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 5 125873847 CAAAAAAAAAAAAAA C rs55932941 ALDH7A1 3.6e-07 -0.21 0.041 0.055 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 18 7174289 C T rs112941827 LAMA1 3.6e-07 -0.43 0.084 0.1 0.1 0 Weight, % change 7.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 2 141239716 A C rs3924456 LRP1B 3.6e-07 -0.53 0.1 0.15 0 Weight, % change 7.2.1_mixedlm_EUR True placebo European ancestry all European (All) 5 60388748 C T rs74432733 NDUFAF2 3.6e-07 0.2 0.038 0.063 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 12 25814594 T C rs10842594 LMNTD1 3.7e-07 0.14 0 HbA1c, % change 1.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 3 5955948 T A rs68087820 EDEM1 3.7e-07 0.25 0.049 0.47 0.47 0 Estimated glomerular filtration rate, % change 15.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 15 35437655 G A rs4923909 NANOGP8 3.7e-07 0.1 0.02 0.27 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 3 3254752 A G rs73111317 CRBN 3.7e-07 0.086 0 Body mass index at 6-months, adj. for baseline 6.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 2 140888409 CT C rs564181702 LRP1B 3.7e-07 0.6 0.12 0.053 0.053 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 16 9152687 T G rs11075185 C16orf72 3.7e-07 0.15 0.029 0.13 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 19 58581821 CA C ZNF135 3.8e-07 0.3 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 22 47034838 T C rs875559 GRAMD4 3.8e-07 0.29 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 2 87561278 A AAAC IGKV3OR2-268 3.8e-07 0.13 0.025 0.43 0.43 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 7 112267856 T G rs1234384 TMEM168 3.8e-07 0.56 0.11 0.099 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 4 3897630 G T rs60592225 ADRA2C 3.8e-07 0.47 0 Heart rate, % change 13.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 13 30074955 C G rs4997529 MTUS2 3.8e-07 0.5 0.099 0.14 0 Estimated glomerular filtration rate, % change 15.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 15 96670699 C T rs61703807 NR2F2 3.8e-07 0.078 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 19 53624774 A G rs62115465 ZNF415 3.8e-07 0.4 0.078 0.3 0 Fasting glucose, % change 3.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 19 6398114 C T rs149679710 GTF2F1 3.8e-07 0.32 0.062 0.14 0.14 0 Body mass index at 6-months, adj. for baseline 6.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 5 153584363 A G rs4958711 GALNT10,MFAP3 3.8e-07 0.067 0.013 0.44 0 Body mass index at 6-months, adj. for baseline 6.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 17 34485994 T G rs2522110 TBC1D3B 3.8e-07 -0.63 0.12 0.21 0 Weight, % change 7.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 12 61787902 GA G TAFA2 3.9e-07 0.28 0 HbA1c, % change 1.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 3 193112917 C T rs12492813 ATP13A4 3.9e-07 0.15 0 HbA1c, % change 1.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 7 141135114 G A rs10224927 TMEM178B 3.9e-07 -0.25 0.049 0.25 0.25 0 HbA1c, % change 1.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 9 29356529 T C rs2383805 LINGO2 3.9e-07 0.27 0.053 0.39 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.1_mixedlm_EUR True placebo European ancestry all European (All) 1 202778061 C T rs41302113 KDM5B 3.9e-07 0.39 0.078 0.16 0.16 0 Estimated glomerular filtration rate, % change 15.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 11 58327177 C T rs74556128 LPXN 3.9e-07 -0.34 0.067 0.11 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 7 77529219 T A rs73375864 PHTF2 3.9e-07 0.059 0 Fasting glucose, % change 3.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 7 105450966 T G rs17152163 ATXN7L1 3.9e-07 0.07 0 Fasting glucose, % change 3.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 2 49343112 G T rs17038288 FSHR 3.9e-07 0.29 0 Body mass index at 6-months, adj. for baseline 6.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 19 14597524 CT C GIPC1 3.9e-07 0.25 0 Weight, % change 7.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 1 192961114 C T rs151293731 UCHL5 3.9e-07 0.93 0.18 0.051 0.051 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 19 2904008 C T rs11673250 ZNF57 4e-07 0.28 0.055 0.32 0.32 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 6 24474402 T C rs57950928 GPLD1 4e-07 0.075 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 1 190068427 TACACAC TACAC BRINP3 4e-07 0.47 0 Estimated glomerular filtration rate, % change 15.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 1 28824467 C T rs150781545 PHACTR4 4e-07 -0.34 0.067 0.064 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 2 17823576 CTT C VSNL1 4e-07 0.076 0 HbA1c at 6-months, adj. for baseline 2.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 5 159045869 G A rs6874625 ADRA1B 4e-07 -0.15 0.03 0.31 0.31 0 Body mass index, % change 5.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 16 54554789 C T rs11076044 IRX3 4e-07 0.73 0 Body mass index at 6-months, adj. for baseline 6.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 6 132934147 C T rs9402433 TAAR2 4e-07 -0.44 0.087 0.28 0 Weight, % change 7.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 4 177512854 T G rs1449739 VEGFC 4e-07 0.44 0.088 0.094 0.094 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 5 7378409 C T rs17207417 ADCY2 4e-07 0.21 0.041 0.053 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 6 39229763 G T rs970392 KCNK5 4e-07 0.13 0 Systolic blood pressure, % change 9.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 13 48085102 A G rs17070244 SUCLA2 4.1e-07 0.22 0.043 0.15 0.15 0 Heart rate at 6-months, adj. for baseline 14.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 5 25894109 C G rs67975124 CDH9 4.1e-07 -0.3 0.059 0.33 0.33 0 Heart rate at 6-months, adj. for baseline 14.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 3 124603058 CAA C rs57376202 ITGB5 4.1e-07 0.4 0 Hypoglycemic events 21.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 19 45323170 CCATCCCCAACTCATCCT C rs3842409 BCAM 4.1e-07 0.11 0.022 0.44 0.56 0 Fasting glucose, % change 3.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 19 56795496 G A rs8104696 EDDM13,ZSCAN5A 4.1e-07 0.81 0 Fasting glucose at 6-months, adj. for baseline 4.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 14 50242455 G A rs143665261 KLHDC2 4.1e-07 0.55 0.11 0.061 0.061 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 8 20031564 T A rs138190016 SLC18A1 4.1e-07 -0.22 0.043 0.053 0 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) 20 52418764 G A rs68186269 BCAS1 4.1e-07 0.15 0 Systolic blood pressure, % change 9.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 2 17823576 CTT C VSNL1 4.2e-07 0.076 0 HbA1c, % change 1.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 6 51297371 CT CTT PKHD1 4.2e-07 0.093 0 HbA1c, % change 1.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 14 104328354 C T rs140741588 PPP1R13B 4.2e-07 -0.96 0.19 0.052 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 3 104553615 GA G rs373505182 ALCAM 4.2e-07 0.066 0 Fasting glucose, % change 3.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 12 50745863 C G rs12317337 FAM186A 4.2e-07 -0.099 0.02 0.38 0 Body mass index at 6-months, adj. for baseline 6.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 14 33872102 A G rs12433945 NPAS3 4.2e-07 0.46 0.091 0.22 0 Systolic blood pressure, % change 9.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 6 32457771 C A rs79044903 HLA-DRB5 4.3e-07 0.4 0.08 0.23 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 1 22912914 C T rs183497128 EPHA8 4.3e-07 0.36 0.071 0.055 0.055 0 Diastolic blood pressure, % change 11.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 15 82425034 G T rs112995593 EFL1 4.3e-07 0.35 0.069 0.38 0 Diastolic blood pressure, % change 11.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 12 11504878 G C rs61930107 PRB1 4.3e-07 0.47 0.092 0.065 0 Heart rate, % change 13.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 13 91691565 C T rs4403919 GPC5 4.3e-07 -0.26 0.052 0.13 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.1_mixedlm_EUR True placebo European ancestry all European (All) 2 210843718 G A rs34678259 UNC80 4.3e-07 0.74 0.15 0.059 0.059 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 19 1735402 C T rs17827916 ONECUT3 4.3e-07 0.91 0.18 0.058 0.058 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 9 112609612 G A rs10816896 PALM2AKAP2 4.4e-07 0.1 0 HbA1c, % change 1.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 19 6920663 G A rs72986346 ADGRE1 4.4e-07 0.2 0 Systolic blood pressure at 6-months, adj. for baseline 10.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 9 19480452 G C rs7855492 SLC24A2 4.4e-07 -0.19 0.038 0.4 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 18 62158789 GCTA G SERPINB8 4.4e-07 -0.16 0.031 0.39 0.61 0 Fasting glucose, % change 3.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 20 45099143 T C rs58953827 ZNF334 4.4e-07 0.53 0.11 0.15 0 Fasting glucose, % change 3.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 10 85953408 A G rs7071722 CDHR1 4.4e-07 0.41 0 Fasting glucose, % change 3.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 14 40471111 GAT G rs35792573 FBXO33 4.4e-07 0.098 0 Fasting glucose at 6-months, adj. for baseline 4.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 16 12175454 C T rs72784646 SNX29 4.4e-07 0.082 0.016 0.38 0 Body mass index at 6-months, adj. for baseline 6.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 8 2918034 C A rs75442393 CSMD1 4.4e-07 -0.13 0.026 0.12 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 1 54310236 T TTTTATTTATTTA NDC1 4.4e-07 -0.22 0.043 0.073 0.927 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 14 49410412 A G rs376649414 RPS29 4.4e-07 0.87 0.17 0.058 0.058 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 1 87890934 T TACCAGTGCCTTCTCTTGAGAATGCAGCTAAACAC rs144893360 LMO4 4.5e-07 0.24 0.048 0.4 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 21 23740087 G GT NCAM2 4.5e-07 -0.32 0.064 0.35 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 21 29157310 AAC A ADAMTS5 4.5e-07 -0.19 0.038 0.21 0.79 0 Diastolic blood pressure, % change 11.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 1 67250214 T C rs79165225 TCTEX1D1 4.5e-07 0.4 0 Fasting glucose, % change 3.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 20 45099143 T C rs58953827 ZNF334 4.5e-07 0.14 0 Fasting glucose, % change 3.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 14 56632838 CT C rs143346535 PELI2 4.5e-07 0.79 0.16 0.075 0.075 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 13 45365172 G T rs7337875 NUFIP1 4.5e-07 0.51 0 Systolic blood pressure, % change 9.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 6 152396352 T C rs2747645 ESR1 4.6e-07 -0.57 0.11 0.092 0.092 0 HbA1c, % change 1.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 15 90300055 G A rs61530581 MESP2 4.6e-07 0.12 0 Fasting glucose, % change 3.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 3 153492693 G A rs7652312 ARHGEF26 4.6e-07 -0.1 0.02 0.18 0 Body mass index at 6-months, adj. for baseline 6.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 14 90225873 CA C EFCAB11 4.6e-07 0.38 0 Weight at 6-months, adj. for baseline 8.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 5 108787558 A ATG PJA2 4.7e-07 -0.32 0.064 0.41 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 3 194774716 T C rs2222146 XXYLT1 4.7e-07 0.17 0.033 0.13 0.87 0 Diastolic blood pressure, % change 11.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 15 73859343 CT C NPTN 4.7e-07 -0.62 0.12 0.23 0 Heart rate, % change 13.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 3 156166374 C T rs10428230 KCNAB1 4.7e-07 -0.41 0.082 0.072 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 3 128669652 C T rs4596167 CFAP92 4.7e-07 0.97 0.19 0.15 0 Hypoglycemic events 21.2.1_coxph_EUR True placebo European ancestry all European (All) 12 56503413 CA C PA2G4 4.7e-07 -0.26 0.052 0.3 0 Fasting glucose, % change 3.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 10 121919013 T C rs6421376 SEC23IP 4.7e-07 0.084 0.017 0.34 0 Body mass index at 6-months, adj. for baseline 6.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 5 121487045 T C rs11956605 AC010255.2,ZNF474 4.7e-07 -0.18 0.036 0.054 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 4 67091414 C G rs546334151 EPHA5 4.7e-07 0.57 0.11 0.057 0.057 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 1 3423102 G A rs75829619 MEGF6 4.7e-07 0.74 0.15 0.059 0.059 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 17 63190869 G C rs76448878 RGS9 4.7e-07 0.86 0.17 0.064 0.064 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 6 32608931 T C rs9272679 HLA-DQA1 4.7e-07 0.4 0.08 0.39 0 Systolic blood pressure, % change 9.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 20 42756127 C CT JPH2 4.8e-07 0.33 0 Diastolic blood pressure, % change 11.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 18 10313183 C A rs169569 APCDD1 4.8e-07 -0.16 0.031 0.33 0.6699999999999999 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 4 95103782 G T rs144228418 SMARCAD1 4.8e-07 0.34 0.068 0.061 0.061 0 HbA1c at 6-months, adj. for baseline 2.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 11 107000535 G A rs10749886 GUCY1A2 4.8e-07 0.75 0.15 2.1 0.4 0.4 0 Hypoglycemic events 21.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 1 88150110 C T rs76763222 LMO4 4.8e-07 1.7 0.34 5.5 0.051 0.051 0 Hypoglycemic events 21.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 28513319 C T rs77511698 AC098650.1,ZCWPW2 4.8e-07 0.054 0 Fasting glucose, % change 3.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 1 228719071 A T rs72763990 RNF187 4.8e-07 -0.12 0.024 0.19 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 3 99311572 T G rs62281782 COL8A1 4.8e-07 0.19 0.038 0.06 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 19 32594822 T C rs8105292 ZNF507 4.8e-07 0.57 0.11 0.14 0.14 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 14 99539770 A T rs807373 BCL11B 4.8e-07 -0.2 0.039 0.34 0.34 0 Systolic blood pressure, % change 9.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 11 20337341 A G rs10430900 HTATIP2 4.9e-07 -0.49 0.097 0.086 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 21 26882706 G A rs2829787 MRPL39 4.9e-07 0.18 0 Heart rate, % change 13.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 1 109069552 G A rs147548658 FAM102B 4.9e-07 -0.53 0.11 0.058 0.058 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 187037369 G A rs12643168 FAM149A 4.9e-07 0.1 0 HbA1c at 6-months, adj. for baseline 2.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 18 9996683 C A rs688085 VAPA 4.9e-07 1.2 0.23 3.2 0.2 0.2 0 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 2 221271724 AT A SLC4A3 4.9e-07 -0.17 0.033 0.096 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 16 64652759 A G rs17487013 CDH11 4.9e-07 0.77 0.15 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 9 107661735 A G rs2777787 ABCA1 4.9e-07 0.4 0 Systolic blood pressure, % change 9.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 1 34477581 A G rs1325258 CSMD2 5e-07 -0.29 0.057 0.17 0.17 0 HbA1c, % change 1.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 5 14573896 C T rs152638 OTULINL 5e-07 0.15 0 Systolic blood pressure at 6-months, adj. for baseline 10.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 16 26617216 T TTGTC rs3054509 C16orf82 5e-07 -0.27 0.053 0.18 0.18 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 21 20181693 T G rs2156204 TMPRSS15 5e-07 -0.11 0.021 0.37 0.63 0 Heart rate at 6-months, adj. for baseline 14.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 6 19225294 G A rs9368049 ID4 5e-07 0.31 0.061 0.18 0 HbA1c at 6-months, adj. for baseline 2.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 3 28513319 C T rs77511698 AC098650.1,ZCWPW2 5e-07 -0.76 0.15 0.051 0.051 0 Fasting glucose, % change 3.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 5 66756356 A G rs2782320 CD180 5e-07 0.23 0.046 0.36 0 Fasting glucose at 6-months, adj. for baseline 4.2.1_mixedlm_EUR True placebo European ancestry all European (All) 10 121840850 G A rs11594290 SEC23IP 5e-07 0.38 0 Body mass index, % change 5.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 7 49621833 G A rs2886379 VWC2 5e-07 0.39 0 Body mass index at 6-months, adj. for baseline 6.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 6 16704690 G GAAGTAAGCCATAATT rs3841158 ATXN1 5e-07 0.19 0 Systolic blood pressure, % change 9.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 9 90835589 G A rs2578246 SPIN1 5.1e-07 -0.45 0.089 0.2 0 Diastolic blood pressure, % change 11.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 6 78726167 A G rs9448270 MEI4 5.1e-07 0.21 0.042 0.45 0 Estimated glomerular filtration rate, % change 15.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 6 40407132 G A rs1865255 LRFN2 5.1e-07 -0.24 0.049 0.098 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 18 77239863 G A rs4567804 NFATC1 5.1e-07 0.46 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 15 37530848 A G rs7176073 MEIS2 5.1e-07 0.34 0.068 0.15 0 HbA1c at 6-months, adj. for baseline 2.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 2 41224923 T C rs13002000 SLC8A1 5.1e-07 -1.0 0.2 0.36 0.26 0.74 0 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 17 4061396 C CT rs140216083 CYB5D2 5.1e-07 -0.46 0.091 0.14 0.14 0 Fasting glucose, % change 3.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 7 153610759 TG T rs11354017 DPP6 5.1e-07 0.37 0 Body mass index at 6-months, adj. for baseline 6.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 15 58223456 G C rs9796698 ALDH1A2 5.1e-07 0.16 0.033 0.084 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 2 169636186 C T rs12104858 CERS6 5.1e-07 0.54 0.11 0.11 0.11 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 17 81038570 C CG rs201014210 METRNL 5.1e-07 0.057 0 Weight at 6-months, adj. for baseline 8.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 6 37818820 CT C ZFAND3 5.1e-07 0.58 0.12 0.13 0.13 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 1 13907413 A G rs99382 PDPN 5.2e-07 -0.43 0.086 0.45 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 6 29889989 C A rs370902 HLA-A 5.2e-07 0.31 0 Diastolic blood pressure at 6-months, adj. for baseline 12.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 3 176592004 C T rs4555533 TBL1XR1 5.2e-07 0.25 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 9 24756636 T A rs34902107 IZUMO3 5.2e-07 0.44 0.087 0.21 0 Fasting glucose at 6-months, adj. for baseline 4.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 10 130356292 G A rs72844013 MKI67 5.2e-07 -0.47 0.093 0.07 0.07 0 Body mass index, % change 5.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 15 102107450 T C rs10902598 PCSK6 5.2e-07 0.17 0.034 0.083 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 12 110507872 G A rs142541823 C12orf76 5.2e-07 -0.85 0.17 0.065 0.065 0 Weight, % change 7.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 1 146689813 A AT rs11391075 FMO5 5.2e-07 -0.18 0.037 0.067 0.933 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 15 87863625 AC A rs34443909 AGBL1 5.3e-07 0.39 0.079 0.46 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 3 170360608 T C rs556346229 AC026316.4 5.3e-07 -1.1 0.21 0.06 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 1 70252919 C T rs12064834 LRRC7 5.3e-07 -0.29 0.058 0.18 0.18 0 Heart rate, % change 13.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 12 77118905 C CATAG ZDHHC17 5.3e-07 -0.4 0.08 0.19 0.19 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 3 153505405 T G rs12636024 ARHGEF26 5.3e-07 -0.34 0.067 0.4 0 Body mass index, % change 5.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 4 144682805 G C rs17694529 FREM3 5.3e-07 -0.092 0.018 0.3 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 11 100929187 C T rs1144133 PGR 5.3e-07 0.67 0.13 0.07 0.07 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 26259182 T C rs59761753 RBPJ 5.4e-07 0.23 0.046 0.25 0.25 0 Diastolic blood pressure, % change 11.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 2 206612714 G A rs12472412 NRP2 5.4e-07 -0.3 0.059 0.17 0.17 0 Heart rate at 6-months, adj. for baseline 14.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 4 121201854 CAA C MAD2L1 5.4e-07 0.63 0 Estimated glomerular filtration rate, % change 15.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 3 171109146 A G rs4894432 TNIK 5.4e-07 0.24 0.047 0.24 0.24 0 Estimated glomerular filtration rate, % change 15.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 6 86757538 T C rs145444693 SYNCRIP 5.4e-07 -0.62 0.12 0.05 0.05 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 15 34516457 A AAAC rs71119950 EMC4 5.4e-07 0.15 0 HbA1c at 6-months, adj. for baseline 2.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 1 99132115 G A rs11166064 SNX7 5.4e-07 -0.1 0.021 0.064 0 Body mass index at 6-months, adj. for baseline 6.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 77741395 T C rs3807730 MAGI2 5.4e-07 0.22 0.044 0.3 0.3 0 Systolic blood pressure, % change 9.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 8 138252568 T C rs118069374 FAM135B 5.5e-07 -0.39 0.077 0.055 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.1_mixedlm_EUR True placebo European ancestry all European (All) 2 74116635 CT C rs11364899 ACTG2 5.5e-07 0.082 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 12 15736430 C A rs35677139 PTPRO 5.5e-07 0.34 0.069 0.3 0 Body mass index, % change 5.2.1_mixedlm_EUR True placebo European ancestry all European (All) 19 13672481 G C rs9967645 CACNA1A 5.5e-07 0.73 0.15 0.059 0.059 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 17 6663477 A G rs12450122 XAF1 5.6e-07 0.45 0.09 0.073 0.073 0 HbA1c, % change 1.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 2 241630513 A G rs1968423 AQP12A 5.6e-07 0.46 0 HbA1c, % change 1.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 8 116866021 C A rs149982932 TRPS1 5.6e-07 0.056 0 Diastolic blood pressure, % change 11.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 15 91216771 G T rs376532532 CRTC3 5.6e-07 0.069 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 19 29808683 G A rs8099873 UQCRFS1 5.6e-07 0.37 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 5 155348825 A G rs17053001 SGCD 5.6e-07 0.064 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 3 194774716 T C rs2222146 XXYLT1 5.6e-07 0.17 0.033 0.13 0.87 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 2 57050007 G T rs12987302 CCDC85A 5.6e-07 0.17 0 Heart rate, % change 13.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 16 3605230 CA C NLRC3 5.6e-07 0.4 0.08 0.21 0 Body mass index, % change 5.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 6 51304633 A G rs9370027 PKHD1 5.6e-07 -0.52 0.1 0.067 0.067 0 Weight, % change 7.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 5 75916603 G A rs2069662 F2RL2,IQGAP2 5.6e-07 0.55 0.11 0.06 0.06 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 1 236411135 A G rs74548460 ERO1B 5.6e-07 0.15 0.029 0.11 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 21 42181304 G A rs62225169 DSCAM 5.6e-07 0.95 0.19 0.052 0.052 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 9 35589534 CA C TESK1 5.7e-07 -0.74 0.15 0.11 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 7 92162042 T C rs10488515 RBM48 5.7e-07 0.084 0 Diastolic blood pressure at 6-months, adj. for baseline 12.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 20 11987516 A AT rs138895950 BTBD3 5.7e-07 0.11 0 Diastolic blood pressure at 6-months, adj. for baseline 12.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 4 117874743 A G rs7688332 TRAM1L1 5.7e-07 0.52 0 Estimated glomerular filtration rate, % change 15.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 2 236778064 T TAAA AGAP1 5.7e-07 0.47 0 Body mass index, % change 5.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 4 107502557 C T rs17358405 GIMD1 5.7e-07 0.75 0.15 0.056 0.056 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 14 25590318 T G rs74570902 STXBP6 5.7e-07 0.79 0.16 0.05 0.05 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 22 46995841 G A rs138548 GRAMD4 5.8e-07 0.5800000000000001 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 5 9221564 A G rs40673 SEMA5A 5.8e-07 0.35 0 Systolic blood pressure at 6-months, adj. for baseline 10.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 1 244202434 T C rs1494122 ZBTB18 5.8e-07 -0.28 0.057 0.31 0 Heart rate at 6-months, adj. for baseline 14.2.1_mixedlm_EUR True placebo European ancestry all European (All) 7 106119635 G A rs10232635 CCDC71L 5.8e-07 -0.22 0.044 0.39 0 HbA1c at 6-months, adj. for baseline 2.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 12 131777146 G T rs71448238 ADGRD1 5.8e-07 1.6 0.32 4.9 0.054 0.054 0 Hypoglycemic events 21.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 5 75425227 T G rs10514059 SV2C 5.8e-07 0.24 0.047 0.32 0 Body mass index, % change 5.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 4 181578872 G T rs80231319 TENM3 5.8e-07 0.18 0.035 0.051 0 Body mass index at 6-months, adj. for baseline 6.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 12 7076236 G C rs2159887 PHB2 5.8e-07 0.83 0 Body mass index at 6-months, adj. for baseline 6.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 18 33141906 C T rs55833596 GALNT1 5.8e-07 -0.2 0.041 0.053 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 15 31849149 T TTA rs34329778 OTUD7A 5.8e-07 -0.19 0.037 0.091 0.909 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 2 48587198 A G rs17037289 FOXN2 5.9e-07 0.24 0 HbA1c, % change 1.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 19 38725570 G A rs12608912 DPF1 5.9e-07 -0.73 0.15 0.072 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 17 5555262 G A rs62075405 NLRP1 5.9e-07 -0.86 0.17 0.062 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 8 85148844 A T rs13274908 RALYL 5.9e-07 -0.13 0.027 0.4 0.4 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 20 60308501 G A rs35900525 CDH4 5.9e-07 0.077 0 HbA1c at 6-months, adj. for baseline 2.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 15 54871505 T G rs2553226 UNC13C 5.9e-07 0.057 0 Fasting glucose, % change 3.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 13 96069174 C G rs2484978 CLDN10 6e-07 0.8200000000000001 0 HbA1c, % change 1.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 19 32836592 G T rs741445 ZNF507 6e-07 -0.26 0.052 0.35 0.35 0 HbA1c, % change 1.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 1 53845440 T C rs2185077 LRP8 6e-07 0.12 0 Diastolic blood pressure at 6-months, adj. for baseline 12.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 5 141070510 A G rs248607 ARAP3 6e-07 0.14 0 Heart rate at 6-months, adj. for baseline 14.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 11 112583877 C A rs116909031 NCAM1 6e-07 -0.34 0.067 0.052 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 16 61990335 GAA G rs71868302 CDH8 6e-07 -0.44 0.087 0.069 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 2 12786284 A G rs35855677 TRIB2 6e-07 -0.25 0.049 0.49 0.49 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 3 62726213 C G rs3846216 CADPS 6e-07 0.099 0 Body mass index at 6-months, adj. for baseline 6.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 5 150554502 T G rs72790178 CCDC69 6e-07 0.064 0 Weight at 6-months, adj. for baseline 8.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 12 27753324 G A rs140803849 PPFIBP1 6e-07 0.96 0.19 0.05 0.05 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 7 152277531 A G rs7789371 XRCC2 6.1e-07 0.15 0 Diastolic blood pressure at 6-months, adj. for baseline 12.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 7 80809290 G T rs7794577 SEMA3C 6.1e-07 -0.21 0.042 0.29 0.29 0 Heart rate, % change 13.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 3 183301270 C G rs3860612 KLHL6 6.1e-07 0.51 0.1 0.14 0.14 0 Urine albumin-to-creatinine ratio, % change 17.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 18 52367433 T C rs9950479 RAB27B 6.1e-07 0.47 0 HbA1c at 6-months, adj. for baseline 2.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 5 78413504 T C rs3797546 BHMT,DMGDH 6.1e-07 0.066 0 Fasting glucose, % change 3.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 3 13793526 G A rs77796192 WNT7A 6.1e-07 -0.74 0.15 0.055 0.055 0 Body mass index at 6-months, adj. for baseline 6.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 20 59384917 G A rs12480686 CDH4 6.1e-07 0.079 0 Systolic blood pressure, % change 9.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 18 6325549 G A rs400243 L3MBTL4 6.2e-07 0.66 0.13 0.055 0.055 0 HbA1c, % change 1.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 12 78963507 A ACTTTCGGAGG rs71441928 SYT1 6.2e-07 0.4 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 2 190492014 T C rs10497705 ASNSD1 6.2e-07 0.28 0.055 0.36 0 Fasting glucose at 6-months, adj. for baseline 4.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 1 67134326 T C rs6692318 SGIP1 6.2e-07 0.15 0 Fasting glucose at 6-months, adj. for baseline 4.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 18 3626587 A C rs28670805 DLGAP1 6.3e-07 -0.25 0.051 0.37 0.37 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 20 6703826 T C rs235762 BMP2 6.3e-07 0.68 0.14 0.056 0 Diastolic blood pressure, % change 11.2.1_mixedlm_EUR True placebo European ancestry all European (All) 16 50190383 G A rs113587860 TENT4B 6.3e-07 -0.74 0.15 0.078 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 19 22038252 G A rs12984073 ZNF43 6.3e-07 0.29 0.059 0.14 0 Heart rate at 6-months, adj. for baseline 14.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 15 70891809 G A rs72755460 UACA 6.3e-07 0.5 0.1 0.093 0.093 0 Heart rate at 6-months, adj. for baseline 14.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 3 189209242 A G rs9865771 TP63 6.3e-07 0.5 0 Fasting glucose, % change 3.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 2 220626803 GA G rs57800314 SLC4A3 6.3e-07 0.074 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 2 85183070 G C rs148185493 KCMF1 6.3e-07 0.058 0 Body mass index at 6-months, adj. for baseline 6.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 4 165598782 A C rs62352338 SMIM31 6.3e-07 -0.12 0.025 0.14 0 Body mass index at 6-months, adj. for baseline 6.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 3 160774460 TA T rs11347558 PPM1L 6.3e-07 0.14 0.029 0.11 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 3 174067529 A T rs75497290 NLGN1 6.3e-07 0.63 0.13 0.079 0.079 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 2 43582055 AG A rs200732171 THADA 6.3e-07 0.06 0 Weight at 6-months, adj. for baseline 8.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 8 130847755 C G rs2724823 CYRIB 6.3e-07 0.43 0 Systolic blood pressure, % change 9.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 6 152547684 T C rs4870085 SYNE1 6.4e-07 0.54 0 HbA1c, % change 1.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 13 28373880 A T rs34058192 GSX1 6.4e-07 -0.64 0.13 0.07 0.07 0 Diastolic blood pressure, % change 11.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 12 64361133 G A rs60052302 SRGAP1 6.4e-07 0.062 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 18 24060731 A C rs59136082 KCTD1 6.4e-07 0.087 0 Estimated glomerular filtration rate, % change 15.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 5 164841237 G T rs185935401 TENM2 6.4e-07 2.2 0.44 8.8 0.057 0.057 0 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) X 17501164 G GC rs11396742 NHS 6.4e-07 0.27 0 Fasting glucose, % change 3.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 5 66285198 C T rs1645239 MAST4 6.4e-07 0.094 0.019 0.19 0.81 0 Body mass index, % change 5.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 12 132966920 G T rs78851903 GALNT9 6.4e-07 0.62 0.13 0.081 0.081 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 9 16218123 A C rs9695809 CCDC171 6.4e-07 0.17 0 Weight at 6-months, adj. for baseline 8.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 13 106606896 G T rs2249748 DAOA 6.4e-07 0.43 0.087 0.066 0 Systolic blood pressure, % change 9.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 18 76733977 C G rs117015489 SALL3 6.5e-07 0.084 0 Heart rate, % change 13.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 15 37526819 C T rs1401893 MEIS2 6.5e-07 0.39 0.079 0.14 0 Fasting glucose at 6-months, adj. for baseline 4.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) X 123760000 C T rs5910103 TENM1 6.5e-07 0.64 0.13 0.077 0.077 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 14 101982026 G A rs1884070 DIO3 6.5e-07 0.59 0.12 0.089 0.089 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 15 72048898 G A rs56039380 THSD4 6.5e-07 0.059 0 Weight at 6-months, adj. for baseline 8.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 14 74583005 CAAAAAAT C rs369107859 LIN52 6.6e-07 -0.35 0.071 0.085 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 19 22156858 T C rs200113618 ZNF208 6.6e-07 1.8 0.36 0.04 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 5 35238047 A G rs7727503 PRLR 6.6e-07 0.44 0 Fasting glucose, % change 3.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 21 20568642 C T rs74651804 TMPRSS15 6.6e-07 0.42 0.084 0.14 0 Systolic blood pressure, % change 9.2.1_mixedlm_EUR True placebo European ancestry all European (All) 14 58066932 G A rs17724195 SLC35F4 6.7e-07 0.41 0.083 0.29 0 HbA1c, % change 1.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 9 127600299 G A rs7875034 WDR38 6.7e-07 0.13 0.027 0.18 0.8200000000000001 0 Diastolic blood pressure, % change 11.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 11 126962153 A T rs117416716 KIRREL3 6.7e-07 -0.46 0.093 0.061 0.061 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 6 127969323 G GGA C6orf58 6.7e-07 1.7 0.33 0.049 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 5 121487045 T C rs11956605 AC010255.2,ZNF474 6.7e-07 0.054 0 Body mass index at 6-months, adj. for baseline 6.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 5 79019599 G GA CMYA5 6.7e-07 0.15 0.031 0.12 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 10 39072082 A T rs144700372 LINC00999 6.7e-07 0.73 0.15 0.059 0.059 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 1 44464654 A AGG SLC6A9 6.8e-07 0.22 0.045 0.24 0 HbA1c, % change 1.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 5 135028007 C CA SLC25A48 6.8e-07 0.33 0 Diastolic blood pressure, % change 11.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 7 147355237 T G rs28407127 CNTNAP2 6.8e-07 0.38 0.076 0.089 0.089 0 Estimated glomerular filtration rate, % change 15.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 17 78854496 C T rs12937510 RPTOR 6.8e-07 0.24 0 Estimated glomerular filtration rate, % change 15.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 7 154256063 G A rs11765373 DPP6 6.8e-07 0.48 0.097 0.14 0 Fasting glucose, % change 3.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 12 126295083 G A rs7313371 TMEM132B 6.8e-07 -0.14 0.028 0.36 0.36 0 Body mass index, % change 5.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 153031885 AT ATGATTT RAP2B 6.8e-07 0.8 0.16 0.11 0 Body mass index, % change 5.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 8 80610179 G A rs112376071 STMN2 6.8e-07 0.78 0.16 0.051 0.051 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 2 39636507 G C rs77317462 MAP4K3 6.8e-07 0.69 0.14 0.065 0.065 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 21 16224456 G A rs74934752 NRIP1 6.9e-07 0.086 0 Diastolic blood pressure, % change 11.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 16 53756739 CA C FTO 6.9e-07 0.42 0.085 0.46 0 Estimated glomerular filtration rate, % change 15.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 15 57162659 G C rs67278720 AC090517.4 6.9e-07 0.17 0 Urine albumin-to-creatinine ratio, % change 17.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 13 95615028 C CT ABCC4 6.9e-07 -0.21 0.042 0.36 0.64 0 HbA1c at 6-months, adj. for baseline 2.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 1 224563159 GT G CNIH4 6.9e-07 -0.22 0.044 0.13 0.87 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 22 45863608 A G rs62224982 FBLN1 6.9e-07 -0.2 0.041 0.056 0 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) 10 99336477 C T rs4244323 ANKRD2 6.9e-07 -0.22 0.044 0.057 0.943 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 11 134763958 G A rs4290245 B3GAT1 7e-07 -0.73 0.15 0.054 0 HbA1c, % change 1.2.2_mixedlm_EUR True placebo European ancestry male European (Males) X 37358194 T A rs57745253 AF241726.1 7e-07 0.055 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 9 137776109 A G rs3128623 FCN2 7e-07 0.28 0.057 0.36 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 3 1256946 C T rs72999894 CNTN6 7e-07 0.41 0.082 0.1 0 Heart rate at 6-months, adj. for baseline 14.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 5 155066776 G A rs4585515 SGCD 7e-07 -1.1 0.22 0.34 0.33 0.6699999999999999 0 Hypoglycemic events 21.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 9 8764808 G A rs201609097 PTPRD 7e-07 -0.17 0.034 0.24 0.24 0 Body mass index, % change 5.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 16 58511896 T C rs13336436 NDRG4 7e-07 -0.13 0.026 0.24 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 18 69312862 AT A CBLN2 7.1e-07 0.47 0 Diastolic blood pressure, % change 11.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 7 97473283 C T rs13230541 ASNS 7.1e-07 0.076 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 2 51058745 T C rs10167695 NRXN1 7.1e-07 -0.17 0.035 0.28 0.28 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 12 25116659 G A rs145023972 BCAT1 7.1e-07 2.0 0.39 0.053 0 Hypoglycemic events 21.2.2_coxph_EUR True placebo European ancestry male European (Males) 2 225017408 A G rs6743478 SERPINE2 7.1e-07 -0.34 0.068 0.15 0 Systolic blood pressure, % change 9.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 3 23819172 T C rs2168426 UBE2E1 7.2e-07 -0.18 0.037 0.46 0 HbA1c, % change 1.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 11 88007909 C T rs10741358 CTSC 7.2e-07 -0.39 0.079 0.096 0.096 0 Estimated glomerular filtration rate, % change 15.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 5 9958839 A G rs2097675 TAS2R1 7.2e-07 0.28 0.057 0.35 0.35 0 Estimated glomerular filtration rate, % change 15.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 22 48444883 CT C TAFA5 7.2e-07 0.74 0 Body mass index, % change 5.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 3 1079515 A C rs4684034 CNTN6 7.2e-07 0.12 0.025 0.12 0.88 0 Body mass index at 6-months, adj. for baseline 6.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 8 102660827 A C rs1892753 GRHL2 7.2e-07 0.23 0 Body mass index at 6-months, adj. for baseline 6.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 5 162743572 T C rs142395214 CCNG1 7.2e-07 0.5 0.1 0.07 0.07 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 15354715 C T rs4685247 SH3BP5 7.2e-07 -0.11 0.023 0.2 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 5 179801065 T A rs145093114 GFPT2 7.2e-07 0.68 0.14 0.068 0.068 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 10 102517900 CT C PAX2 7.2e-07 0.92 0.19 0.053 0.053 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 5 43220395 C CT NIM1K 7.2e-07 0.32 0 Systolic blood pressure, % change 9.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 12 96012114 G A rs4762578 NTN4 7.3e-07 0.2 0.041 0.41 0 Heart rate at 6-months, adj. for baseline 14.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 2 20329092 G T rs13019898 SDC1 7.3e-07 0.24 0.048 0.23 0.23 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 2 51381378 C G rs17041346 NRXN1 7.3e-07 0.069 0 HbA1c at 6-months, adj. for baseline 2.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 6 51297371 CT CTT PKHD1 7.3e-07 0.091 0 HbA1c at 6-months, adj. for baseline 2.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 10 33717091 AT A NRP1 7.3e-07 -0.27 0.055 0.2 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 18 7010428 C G rs74825364 LAMA1 7.3e-07 0.62 0.13 0.077 0.077 0 Body mass index, % change 5.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 4 102596697 C T rs10029986 BANK1 7.3e-07 0.41 0 Body mass index at 6-months, adj. for baseline 6.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 16 4000204 G C rs17136625 ADCY9 7.3e-07 0.052 0 Weight at 6-months, adj. for baseline 8.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 10 19078445 G A rs111765057 ARL5B 7.3e-07 0.055 0 Systolic blood pressure, % change 9.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 6 152396352 T C rs2747645 ESR1 7.4e-07 0.086 0 HbA1c, % change 1.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 12 73012573 T G rs11613768 TRHDE 7.4e-07 0.12 0 Systolic blood pressure at 6-months, adj. for baseline 10.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 10 68336295 T C rs10997242 CTNNA3 7.4e-07 0.29 0.058 0.16 0.16 0 Diastolic blood pressure, % change 11.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 62577213 C T rs7679977 ADGRL3 7.4e-07 0.61 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 5 145733633 C T rs11748968 POU4F3 7.4e-07 0.59 0.12 0.091 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 4 121149877 C T rs13134323 MAD2L1 7.4e-07 0.32 0 Estimated glomerular filtration rate, % change 15.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 12 43636353 C A rs11181974 ADAMTS20 7.4e-07 0.17 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 10 2050303 G A rs35168688 ADARB2 7.4e-07 0.13 0 HbA1c at 6-months, adj. for baseline 2.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 3 190157542 A C rs9851374 TMEM207 7.4e-07 -0.2 0.041 0.37 0.63 0 Weight, % change 7.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 9 752104 G T rs12002168 KANK1 7.4e-07 -0.45 0.091 0.23 0.23 0 Weight, % change 7.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 3 182244521 A T rs9838672 ATP11B 7.4e-07 -0.18 0.037 0.073 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 1 58485443 G A rs1188004 DAB1 7.5e-07 -0.15 0.031 0.45 0.55 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 17 53598932 C A rs73990429 SMIM36 7.5e-07 0.057 0 Heart rate, % change 13.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 4 126577457 TG T rs202110854 FAT4 7.5e-07 0.85 0.17 0.072 0 Fasting glucose, % change 3.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 13 110962520 C T rs7334306 COL4A2 7.5e-07 -0.65 0.13 0.18 0 Fasting glucose, % change 3.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 11 75263589 T A rs200646551 SERPINH1 7.5e-07 -0.3 0.062 0.26 0.26 0 Body mass index at 6-months, adj. for baseline 6.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 19 48904523 A G rs7246448 GRIN2D 7.5e-07 0.82 0.17 0.068 0.068 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 11 80930377 T C rs12419987 FAM181B 7.6e-07 -0.4 0.08 0.18 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.2_mixedlm_EUR True placebo European ancestry male European (Males) X 154746 A T rs145770603 ENSG00000182378.15_10 7.6e-07 0.49 0.1 0.091 0 HbA1c at 6-months, adj. for baseline 2.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) X 93013489 G A rs73252253 FAM133A 7.6e-07 0.14 0 Fasting glucose at 6-months, adj. for baseline 4.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 18 52886637 A T rs1787792 TCF4 7.6e-07 0.19 0.038 0.37 0.37 0 Body mass index, % change 5.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 9 78917340 G A rs2842474 PCSK5 7.7e-07 0.18 0.036 0.49 0 HbA1c, % change 1.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 21 23205367 T TC rs397959523 NCAM2 7.7e-07 -0.37 0.076 0.12 0 HbA1c, % change 1.2.1_mixedlm_EUR True placebo European ancestry all European (All) 10 64292836 A T rs7086948 AC024598.1 7.7e-07 0.5900000000000001 0 Heart rate, % change 13.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 15 71082936 A T rs6494890 UACA 7.7e-07 -0.1 0.021 0.33 0.6699999999999999 0 Estimated glomerular filtration rate, % change 15.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 10 67930797 A G rs10740224 CTNNA3 7.7e-07 0.75 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 13 24877445 T C rs11149059 AL359736.1,SPATA13 7.7e-07 -0.27 0.055 0.24 0 HbA1c at 6-months, adj. for baseline 2.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 1 193577742 T C rs61831964 CDC73 7.7e-07 2.2 0.45 9.2 0.051 0.051 0 Hypoglycemic events 21.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 2 68685988 T A rs7425346 FBXO48 7.7e-07 0.77 0.16 0.07 0.07 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 2 104493567 A G rs73945982 TMEM182 7.8e-07 -0.28 0.057 0.14 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 1 181388963 T C rs10910933 CACNA1E 7.8e-07 -0.36 0.073 0.28 0 Urine albumin-to-creatinine ratio, % change 17.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 9 9193458 T C rs74987532 PTPRD 7.8e-07 0.066 0 Fasting glucose, % change 3.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 15 72049440 A G rs145667035 THSD4 7.8e-07 -0.49 0.099 0.054 0.054 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 3 196066569 G A rs7636047 TM4SF19 7.9e-07 0.44 0.089 0.19 0 HbA1c, % change 1.2.3_mixedlm_EUR True placebo European ancestry female European (Females) X 138144111 CTTA C rs35979757 FGF13 7.9e-07 -0.29 0.058 0.17 0.17 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 19 38725570 G A rs12608912 DPF1 7.9e-07 0.075 0 Systolic blood pressure at 6-months, adj. for baseline 10.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 3 132531279 T TC rs370820700 NPHP3-ACAD11 7.9e-07 -0.25 0.051 0.38 0 Heart rate, % change 13.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 94699936 C T rs12704777 PPP1R9A 7.9e-07 -0.36 0.073 0.19 0 Urine albumin-to-creatinine ratio, % change 17.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 63311141 G A rs111233877 ZNF722P 7.9e-07 -0.77 0.16 0.063 0 Fasting glucose, % change 3.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 2 49247646 ATT A FSHR 7.9e-07 -0.18 0.037 0.4 0.4 0 Body mass index at 6-months, adj. for baseline 6.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 17 46815835 C G rs1343832 HOXB13 7.9e-07 0.17 0.034 0.091 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 11 73335505 GA G PLEKHB1 8e-07 -0.42 0.084 0.33 0 Diastolic blood pressure, % change 11.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 18 35637871 C T rs2129096 CELF4 8e-07 -0.22 0.045 0.29 0.29 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 6 96489687 T C rs753501 FUT9 8e-07 0.62 0.13 0.054 0 Urine albumin-to-creatinine ratio, % change 17.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 17 6958841 A G rs4796578 SLC16A11 8e-07 0.37 0.075 0.21 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 3 100822347 G GAGAAAGGAAA rs142647168 ABI3BP 8e-07 0.39 0.079 0.11 0.11 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 2 169636186 C T rs12104858 CERS6 8e-07 0.15 0.031 0.1 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 12 72143520 C T rs11178927 RAB21 8.1e-07 0.067 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 19 5701533 G A rs150473648 LONP1 8.1e-07 -0.27 0.054 0.2 0.2 0 Estimated glomerular filtration rate, % change 15.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 10 33956624 GT G NRP1 8.1e-07 0.13 0 Urine albumin-to-creatinine ratio, % change 17.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 18 23396250 C A rs7242747 SS18 8.1e-07 -0.36 0.073 0.31 0 Fasting glucose at 6-months, adj. for baseline 4.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 5 73041784 A G rs952995 ARHGEF28 8.1e-07 -0.44 0.089 0.24 0 Weight, % change 7.2.1_mixedlm_EUR True placebo European ancestry all European (All) 4 24290150 T C rs34526542 DHX15 8.2e-07 0.4 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 6 121081774 GATTT G rs67033980 TBC1D32 8.2e-07 0.5800000000000001 0 Heart rate at 6-months, adj. for baseline 14.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 9 9625553 AT A PTPRD 8.2e-07 0.41 0 HbA1c at 6-months, adj. for baseline 2.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 13 107884392 T C rs61965569 FAM155A 8.2e-07 0.33 0 Fasting glucose at 6-months, adj. for baseline 4.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 3 153506699 A AT ARHGEF26 8.2e-07 -0.28 0.056 0.091 0.091 0 Body mass index, % change 5.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 4 3601379 T TG LRPAP1 8.2e-07 0.65 0.13 0.072 0 Systolic blood pressure, % change 9.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 4 119226291 C T rs200483108 PRSS12 8.3e-07 0.087 0 HbA1c, % change 1.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 5 144764597 G C rs282463 PRELID2 8.3e-07 0.31 0 Diastolic blood pressure at 6-months, adj. for baseline 12.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 13 91681298 TCA TCACA GPC5 8.3e-07 -0.48 0.097 0.055 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 5 58682821 C T rs6887017 PDE4D 8.3e-07 0.17 0 HbA1c at 6-months, adj. for baseline 2.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 14 41622611 C CATAT LRFN5 8.3e-07 -0.11 0.022 0.4 0.6 0 Fasting glucose, % change 3.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 19 52151222 G C rs11673200 AC018755.2 8.4e-07 -0.2 0.04 0.37 0.37 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 19 17544244 C T rs34189069 MVB12A 8.4e-07 0.39 0 Diastolic blood pressure at 6-months, adj. for baseline 12.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 3 152761474 T G rs17454914 RAP2B 8.4e-07 -0.34 0.07 0.11 0.11 0 Heart rate, % change 13.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 15 74288047 G T rs12911485 PML 8.4e-07 -0.27 0.056 0.43 0 Fasting glucose at 6-months, adj. for baseline 4.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 12 27836249 C T rs11049094 PPFIBP1 8.4e-07 0.44 0.089 0.13 0.13 0 Body mass index, % change 5.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 4 102596697 C T rs10029986 BANK1 8.4e-07 0.18 0.037 0.4 0.4 0 Body mass index at 6-months, adj. for baseline 6.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 1 181405444 T G rs594798 CACNA1E 8.4e-07 0.61 0.12 0.082 0.082 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 18 3194907 T TA MYOM1 8.5e-07 -0.4 0.081 0.11 0 HbA1c, % change 1.2.1_mixedlm_EUR True placebo European ancestry all European (All) 11 45595980 T C rs1488681 CHST1 8.5e-07 0.74 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 19 17505859 C T rs8102244 CCDC194 8.5e-07 0.72 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 7 13738911 T G rs78953727 ETV1 8.5e-07 0.051 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 7 106090090 G A rs7798278 NAMPT 8.5e-07 -0.2 0.042 0.4 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 11 69721934 A G FGF3 8.5e-07 0.72 0 Fasting glucose at 6-months, adj. for baseline 4.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 18 2451547 A C rs3859380 METTL4 8.5e-07 0.34 0.069 0.39 0.39 0 Weight, % change 7.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 6 10128271 G T rs10456848 TFAP2A 8.5e-07 0.19 0 Weight at 6-months, adj. for baseline 8.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 4 24429631 G A rs115650862 DHX15 8.5e-07 0.86 0.17 0.061 0.061 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 5 112463377 G A rs2197280 MCC 8.5e-07 0.53 0.11 0.29 0 Systolic blood pressure, % change 9.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 21 24402849 C T rs79386186 NCAM2 8.6e-07 0.056 0 HbA1c, % change 1.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 2 20101487 G A rs2304589 TTC32 8.6e-07 -0.33 0.067 0.17 0 HbA1c, % change 1.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 3 152752806 G C rs7644645 RAP2B 8.6e-07 -0.37 0.076 0.12 0 Heart rate at 6-months, adj. for baseline 14.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 2 20101487 G A rs2304589 TTC32 8.6e-07 -0.29 0.058 0.17 0 HbA1c at 6-months, adj. for baseline 2.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 9 14054403 C T rs75726676 NFIB 8.6e-07 0.053 0 HbA1c at 6-months, adj. for baseline 2.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 5 41263324 G C rs10077836 C6 8.6e-07 0.14 0 Fasting glucose, % change 3.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 3 29387631 G A rs7610043 AC098650.1,RBMS3 8.6e-07 0.36 0.073 0.49 0 Fasting glucose, % change 3.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 7 144306250 C CA TPK1 8.6e-07 0.062 0 Body mass index, % change 5.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 6 137897580 TTA TTTTATATA OLIG3 8.6e-07 -0.11 0.022 0.21 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 7 49843453 C G rs17133503 VWC2 8.6e-07 0.16 0.032 0.099 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 14 83119689 C CT SEL1L 8.6e-07 0.094 0 Weight at 6-months, adj. for baseline 8.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 4 14048930 A G rs3846363 BOD1L1 8.6e-07 -0.22 0.045 0.093 0.907 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 4 39441069 C CTGTTGT KLB 8.6e-07 0.33 0 Systolic blood pressure, % change 9.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 2 178141063 A G rs2364730 NFE2L2 8.6e-07 -0.27 0.055 0.39 0.39 0 Systolic blood pressure, % change 9.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 3 3512542 T A rs28367282 SUMF1 8.7e-07 0.27 0.054 0.29 0 HbA1c, % change 1.1.2_mixedlm_EUR True saxagliptin European ancestry male European (Males) 22 43539651 G A rs5759182 MCAT 8.7e-07 0.86 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 1 205327237 A G rs12140669 KLHDC8A 8.7e-07 -0.22 0.044 0.39 0 Diastolic blood pressure, % change 11.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 1 73998967 T G rs78497794 LRRIQ3 8.7e-07 -0.71 0.14 0.055 0.055 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 8 129462454 A T rs112260545 MYC 8.7e-07 -0.45 0.092 0.27 0 Estimated glomerular filtration rate, % change 15.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 1 18554000 G C rs1341304 IGSF21 8.7e-07 0.31 0.063 0.23 0 Urine albumin-to-creatinine ratio, % change 17.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 54001621 G A rs1852384 VSTM2A 8.7e-07 0.18 0.037 0.23 0 HbA1c at 6-months, adj. for baseline 2.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 5 84968745 T C rs10473899 COX7C 8.8e-07 0.64 0 HbA1c, % change 1.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 6 29923351 G A rs2904758 HLA-A 8.8e-07 0.13 0.027 0.26 0.74 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 140563092 TA T MGST2 8.8e-07 -0.19 0.039 0.43 0.43 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 11 116493950 T G rs1240659 BUD13 8.8e-07 -0.2 0.041 0.17 0.17 0 Body mass index, % change 5.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 18 77635553 G A rs62103232 KCNG2 8.8e-07 0.13 0 Body mass index, % change 5.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 5 162696727 ATT A rs35563372 CCNG1 8.8e-07 -0.68 0.14 0.063 0.063 0 Body mass index at 6-months, adj. for baseline 6.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 4 16760152 T A rs76716863 LDB2 8.8e-07 0.87 0.18 0.054 0.054 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 16 80864846 T A rs1423857 AC009070.1 8.9e-07 0.5 0 Systolic blood pressure at 6-months, adj. for baseline 10.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 5 7287719 CT C ADCY2 8.9e-07 0.26 0.052 0.13 0.13 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 6 32695455 C T rs78705254 HLA-DQA2 8.9e-07 -0.56 0.11 0.077 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 13 42982302 A C rs2147161 AKAP11 8.9e-07 -0.3 0.061 0.43 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 12 12110232 C A rs34939024 ETV6 8.9e-07 0.22 0 Fasting glucose, % change 3.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) X 43480664 A AAAAT MAOA 8.9e-07 0.64 0 Body mass index, % change 5.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 18 46327155 G A rs76667091 CTIF 8.9e-07 -0.17 0.034 0.06 0 Body mass index at 6-months, adj. for baseline 6.2.1_mixedlm_EUR True placebo European ancestry all European (All) 7 78692723 A G rs10953759 MAGI2 8.9e-07 0.19 0.039 0.06 0 Body mass index at 6-months, adj. for baseline 6.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 13 114478005 T C rs528270469 TMEM255B 8.9e-07 0.72 0.15 0.087 0.087 0 Weight at 6-months, adj. for baseline 8.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 12 4937590 C T rs2359468 GALNT8 9e-07 -0.15 0.03 0.42 0.5800000000000001 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) X 139036872 AAAC AAACAACAACAACAACAACAAC rs78312389 CXorf66 9e-07 1.1 0.22 0.052 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 6 70987976 G A rs3806095 COL9A1 9e-07 0.16 0.032 0.28 0.28 0 Fasting glucose, % change 3.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 3 62726213 C G rs3846216 CADPS 9e-07 -0.51 0.1 0.092 0.092 0 Body mass index, % change 5.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 8 102660252 C T rs10091039 GRHL2 9e-07 0.11 0 Systolic blood pressure, % change 9.5_gwama_inter_C_F_M_EUR True placebo European ancestry sex all European (All) 6 51297371 CT CTT PKHD1 9.1e-07 0.068 0 HbA1c, % change 1.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 1 163516929 TA T rs565871791 NUF2 9.1e-07 0.076 0 HbA1c, % change 1.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) X 120865030 G A rs1334447 GLUD2 9.1e-07 0.32 0 HbA1c, % change 1.2_gwama_inter_I_male_vs_C_males_EUR True both European ancestry treatment male European (Males) 16 1846241 C T rs7197536 HAGH 9.1e-07 0.15 0 Systolic blood pressure at 6-months, adj. for baseline 10.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 14 102399354 T A rs8007030 PPP2R5C 9.1e-07 0.67 0.14 0.071 0 Heart rate at 6-months, adj. for baseline 14.2.2_mixedlm_EUR True placebo European ancestry male European (Males) X 10098330 A G rs2285498 WWC3 9.1e-07 0.42 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 10 11875716 A C rs7899079 PROSER2 9.1e-07 0.19 0.039 0.38 0.62 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.2.2_gmmat_all True placebo multi-ancestry male Multi-ancestry (Males) 2 153080677 A T rs76591569 STAM2 9.1e-07 0.77 0.16 0.051 0.051 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) X 31420919 C A rs10126367 DMD 9.1e-07 0.49 0.099 0.17 0.17 0 Weight at 6-months, adj. for baseline 8.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 11 97569984 T C rs11212338 CNTN5 9.1e-07 -0.32 0.065 0.12 0.12 0 Systolic blood pressure, % change 9.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 10 60505362 G GC BICC1 9.1e-07 0.46 0 Systolic blood pressure, % change 9.3_gwama_inter_I_females_vs_C_females_EUR True both European ancestry treatment female European (Females) 20 4438261 C T rs57698607 ADRA1D 9.2e-07 -0.58 0.12 0.081 0.081 0 Systolic blood pressure at 6-months, adj. for baseline 10.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 4 28502443 G A rs292058 STIM2 9.2e-07 -0.11 0.023 0.46 0.54 0 Heart rate, % change 13.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 9 89971793 C CA DAPK1 9.2e-07 0.36 0 Urine albumin-to-creatinine ratio, % change 17.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 8 89169920 C T rs1915011 MMP16 9.2e-07 0.41 0.084 0.43 0 Urine albumin-to-creatinine ratio, % change 17.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 18 62158789 GCTA G SERPINB8 9.2e-07 -0.15 0.031 0.39 0.61 0 Fasting glucose at 6-months, adj. for baseline 4.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 1 204612679 G A rs7533494 LRRN2 9.2e-07 -0.19 0.038 0.055 0 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) 9 7004340 A G rs10975965 KDM4C 9.3e-07 -0.71 0.14 0.084 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 11 112583877 C A rs116909031 NCAM1 9.3e-07 -0.51 0.1 0.052 0 Estimated glomerular filtration rate, % change 15.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 5 166618 T C rs13184884 PLEKHG4B 9.3e-07 0.11 0 HbA1c at 6-months, adj. for baseline 2.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 6 17424537 A G rs9370987 CAP2 9.3e-07 2.5 0.5 12.0 0.065 0.065 0 Hypoglycemic events 21.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 15 53557936 C G rs1386172 WDR72 9.3e-07 0.12 0.024 0.093 0.907 0 Fasting glucose at 6-months, adj. for baseline 4.2.1_gmmat_all True placebo multi-ancestry all Multi-ancestry (All) 5 66287598 A G rs39664 MAST4 9.3e-07 0.091 0.018 0.17 0.83 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 1 223173525 T A rs111416089 DISP1 9.3e-07 0.066 0 Weight at 6-months, adj. for baseline 8.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 3 79338242 A AT ROBO1 9.3e-07 0.22 0.045 0.05 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 7 94249 C T rs6962041 FAM20C 9.3e-07 0.43 0.088 0.15 0 Systolic blood pressure, % change 9.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 7 70342216 T G rs13244537 AUTS2 9.4e-07 0.16 0.032 0.47 0.53 0 HbA1c, % change 1.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 1 18554000 G C rs1341304 IGSF21 9.4e-07 0.47 0.095 0.24 0 Urine albumin-to-creatinine ratio, % change 17.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) X 816862 T G rs5946507 ENSG00000185960.14_6 9.4e-07 -0.19 0.038 0.24 0 Fasting glucose at 6-months, adj. for baseline 4.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) X 99517689 A G rs5967105 PCDH19 9.4e-07 0.086 0 Fasting glucose at 6-months, adj. for baseline 4.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) 7 89450455 T C rs2373996 STEAP1 9.4e-07 0.068 0 Body mass index, % change 5.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 7 124797486 A G rs2402770 POT1 9.4e-07 -0.49 0.1 0.12 0 Body mass index, % change 5.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 5 50381531 T C rs4317281 PARP8 9.4e-07 0.4 0.081 0.082 0.082 0 Body mass index at 6-months, adj. for baseline 6.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 17 34485994 T G rs2522110 TBC1D3B 9.4e-07 -0.48 0.098 0.2 0 Weight, % change 7.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 15 101922323 A G rs1058260 PCSK6 9.4e-07 -0.37 0.075 0.22 0.22 0 Weight, % change 7.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 13 101889517 C T rs9513874 NALCN 9.4e-07 0.38 0 Systolic blood pressure, % change 9.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 2 220511146 T C rs687477 SLC4A3 9.5e-07 -0.13 0.026 0.15 0.85 0 Heart rate, % change 13.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 6 40406923 A G rs4714347 LRFN2 9.5e-07 0.073 0 Estimated glomerular filtration rate at 6-months, adj. for baseline 16.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 12 105046934 T C rs2694408 CHST11 9.5e-07 0.908 0 HbA1c at 6-months, adj. for baseline 2.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 21 38356837 G A rs2843961 HLCS 9.5e-07 -0.2 0.042 0.33 0.6699999999999999 0 Fasting glucose, % change 3.2.3_gmmat_all True placebo multi-ancestry female Multi-ancestry (Females) 8 11746122 T C rs11783694 CTSB 9.5e-07 0.45 0.091 0.3 0 Body mass index, % change 5.2.2_mixedlm_EUR True placebo European ancestry male European (Males) 18 76733977 C G rs117015489 SALL3 9.6e-07 0.084 0 Heart rate at 6-months, adj. for baseline 14.2.2_gwama_inter_C_F_M_all True placebo multi-ancestry sex all Multi-ancestry (All) 3 120250293 T G rs1982187 NDUFB4 9.6e-07 -0.31 0.064 0.086 0.086 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 21 25585177 C A rs12483524 MRPL39 9.6e-07 0.23 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.2_gwama_inter_I_male_vs_C_males_all True both multi-ancestry treatment male Multi-ancestry (Males) 10 14793995 G T rs12244530 FAM107B 9.7e-07 0.063 0 Diastolic blood pressure, % change 11.1.3_gwama_inter_I_females_vs_C_females_all True both multi-ancestry treatment female Multi-ancestry (Females) 15 53030318 G A rs72740254 ONECUT1 9.7e-07 0.32 0.066 0.13 0 HbA1c at 6-months, adj. for baseline 2.1.3_mixedlm_EUR True saxagliptin European ancestry female European (Females) 18 52886637 A T rs1787792 TCF4 9.7e-07 0.38 0 Body mass index, % change 5.1.2_gwama_inter_I_F_M_all True saxagliptin multi-ancestry sex all Multi-ancestry (All) X 143840452 C T rs62598755 SPANXN1 9.7e-07 0.2 0.04 0.058 0 Weight at 6-months, adj. for baseline 8.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 1 108075408 A G rs17019355 VAV3 9.7e-07 -0.12 0.024 0.17 0 Weight at 6-months, adj. for baseline 8.2.1_mixedlm_EUR True placebo European ancestry all European (All) 7 148327260 A G rs713590 C7orf33 9.8e-07 0.065 0 Diastolic blood pressure at 6-months, adj. for baseline 12.1.1_gwama_inter_I_all_vs_C_all_all True both multi-ancestry treatment all Multi-ancestry (All) 1 102013132 T C rs77913085 OLFM3 9.8e-07 -0.66 0.13 0.1 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 5 73259609 C T rs17733586 ARHGEF28 9.8e-07 -0.81 0.17 0.064 0 Diastolic blood pressure at 6-months, adj. for baseline 12.2.3_mixedlm_EUR True placebo European ancestry female European (Females) 9 4257586 T TTGTTGTTGTTG rs376998444 GLIS3 9.8e-07 1.2 0.24 0.14 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 8 122842632 T C rs72609838 HAS2 9.8e-07 0.24 0.049 0.12 0 Fasting glucose at 6-months, adj. for baseline 4.1.1_mixedlm_EUR True saxagliptin European ancestry all European (All) 6 117994158 G A rs13211542 NUS1 9.8e-07 0.17 0.034 0.25 0.25 0 Body mass index at 6-months, adj. for baseline 6.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 5 135424352 G A rs6596283 TGFBI 9.8e-07 0.48 0.099 0.074 0.074 0 Weight at 6-months, adj. for baseline 8.1.1_gmmat_all True saxagliptin multi-ancestry all Multi-ancestry (All) 10 38534936 A G rs148687139 PLD5P1 9.8e-07 0.76 0.15 0.052 0.052 0 Weight at 6-months, adj. for baseline 8.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 1 161306983 T G rs34006306 SDHC 9.8e-07 0.066 0 Weight at 6-months, adj. for baseline 8.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All) 17 18848023 A G rs1737939 SLC5A10 9.9e-07 -0.16 0.032 0.48 0.52 0 Diastolic blood pressure, % change 11.1.2_gmmat_all True saxagliptin multi-ancestry male Multi-ancestry (Males) 4 20242529 G A rs559767 SLIT2 9.9e-07 -0.16 0.033 0.31 0.69 0 Urine albumin-to-creatinine ratio at 6-months, adj. for baseline 18.1.3_gmmat_all True saxagliptin multi-ancestry female Multi-ancestry (Females) 4 116375909 G A rs150013055 NDST4 9.9e-07 2.3 0.48 0.012 0 Hypoglycemic events 21.1.1_coxph_EUR True saxagliptin European ancestry all European (All) 12 50729907 C CA FAM186A 9.9e-07 0.13 0 Body mass index, % change 5.4_gwama_inter_I_F_M_EUR True saxagliptin European ancestry sex all European (All) 12 129157292 C T rs11059821 TMEM132C 9.9e-07 0.12 0 Weight, % change 7.1_gwama_inter_I_all_vs_C_all_EUR True both European ancestry treatment all European (All)